All Phenotypes Mecp2<tm1.1Jtc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mecp2^tm1.1Jtc
targeted mutation 1.1, Joseph T Coyle
MGI:5568206

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mecp2^tm1.1Jtc/Mecp2^tm1.1Jtc	involves: 129S6/SvEvTac * 129/SvJ	MGI:5568215
ht2	Mecp2^tm1.1Jtc/Mecp2⁺	involves: 129S6/SvEvTac * C57BL/6	MGI:5568998
ot3	Mecp2^tm1.1Jtc/Y	involves: 129S6/SvEvTac * 129/SvJ	MGI:5568214
ot4	Mecp2^tm1.1Jtc/Y	involves: 129S6/SvEvTac * C57BL/6	MGI:5568994

Allelic Composition	Mecp2^tm1.1Jtc/Mecp2^tm1.1Jtc
Genetic Background	involves: 129S6/SvEvTac * 129/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1.1Jtc mutation (1 available); any Mecp2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

limb grasping ( J:127431 )

• female mice exhibit hindlimb clasping by 6 months of age

mortality/aging

premature death ( J:127431 )

• most females die before a year, however, some females survive to more than a year

• lifespan is longer than in males

respiratory system

abnormal breathing pattern ( J:127431 )

• female mice exhibit breathing irregularities by 6 months of age

Allelic Composition	Mecp2^tm1.1Jtc/Mecp2⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1.1Jtc mutation (1 available); any Mecp2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired long-term object recognition memory ( J:209637 )

• object memory is intact at 1 hour, but impaired at 24 hours after object training, however, the impairment occurs to a lesser degree than in males

increased fear-related response ( J:209637 )

• females freeze for a larger percentage of time during the acquisition phase of the associative fear conditioning task as compared to wild type on day 80, but not on postnatal day 40

impaired coordination ( J:209637 )

• reduced latency to fall from rotarod as compared to wild type on postnatal day 30

decreased locomotor activity ( J:209637 )

• reduced ambulatory movements (two consecutive beam breaks) as compared to wild type on postnatal day 63

• reduced fine motor movements (repeated breaking of same beam) as compared to wild type on postnatal day 63

tonic-clonic seizures ( J:209637 )

• tonic-clonic seizures observed in 3.7% (5/136) of females

• seizures appear to be stimulated by touch

• mice die within a month of seizures

growth/size/body

decreased body weight ( J:209637 )

• reduced body weight as compared to wild type on postnatal day 64

nervous system

tonic-clonic seizures ( J:209637 )

• tonic-clonic seizures observed in 3.7% (5/136) of females

• seizures appear to be stimulated by touch

• mice die within a month of seizures

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:209637

Allelic Composition	Mecp2^tm1.1Jtc/Y
Genetic Background	involves: 129S6/SvEvTac * 129/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1.1Jtc mutation (1 available); any Mecp2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

limb grasping ( J:127431 )

• male mice exhibit hindlimb clasping by 7 weeks of age

decreased locomotor activity ( J:127431 )

• male mice exhibit hypoactivity

increased stereotypic behavior ( J:127431 )

• male mice exhibit forelimb stereotypies

growth/size/body

abnormal body weight ( J:127431 )

• male mice exhibit great variability in weight

slow postnatal weight gain ( J:127431 )

• some male mice exhibit failure to thrive

obese ( J:127431 )

• a subset of male mice have excessive weight gain

mortality/aging

premature death ( J:127431 )

• average lifespan in males is 85.8 +/-24.2 days

respiratory system

abnormal breathing pattern ( J:127431 )

• male mice exhibit breathing irregularities by 7 weeks of age

Allelic Composition	Mecp2^tm1.1Jtc/Y
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2^tm1.1Jtc mutation (1 available); any Mecp2 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

lethargy ( J:209637 )

• mice appear lethargic by postnatal day 50

impaired long-term object recognition memory ( J:209637 )

• object memory is intact at 1 hour, but impaired 24 hours after object training

increased anxiety-related response ( J:209637 )

• increased time spent in open arms as compared to wild type on postnatal day 25

• increased number of open arm entries as compared to wild type on on postnatal day 25

• increased travel distance in zero maze as compared to wild type control on postnatal day 25

increased fear-related response ( J:209637 )

• males freeze for a larger percentage of time as compared to wild type on postnatal day 35, however, males freeze for smaller percentage of time on both context and cued memory tasks

impaired coordination ( J:209637 )

• reduced latency to fall from rotarod as compared to wild type on postnatal day 29

decreased grip strength ( J:209637 )

• decreased forelimb grip strength as compared to wild type on postnatal day 25

decreased locomotor activity ( J:209637 )

• reduced ambulatory movements (two consecutive beam breaks) as compared to wild type first observed at postnatal day 24

• reduced fine motor movements (repeated breaking of same beam) as compared to wild type observed at postnatal day 43

growth/size/body

decreased body weight ( J:209637 )

• reduced body weight as compared to wild type on postnatal day 25

integument

ruffled hair ( J:209637 )

• ruffled fur observed by postnatal day 50

respiratory system

abnormal respiration ( J:209637 )

• respiratory abnormalities observed by postnatal day 50

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:209637

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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