Phenotypes associated with this allele

• Allele Symbol: Mir192^tm1.1Rnat
• Allele Name: targeted mutation 1.1, Rama Natarajan
• Allele ID: MGI:5568207
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir192^tm1.1Rnat/Mir192^tm1.1Rnat	involves: 129	MGI:5568211

Genotype
MGI:5568211

hm1

• Allelic Composition: Mir192^tm1.1Rnat/Mir192^tm1.1Rnat
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal urine protein level ( J:208963 )

• attenuated progressive proteinuria and albuminuria in streptozotocin-treated mice at 22 weeks

abnormal kidney morphology ( J:208963 )

• streptozotocin-treated mice exhibit an attenuated increase in glomerular area, mesangial matrix expansion and diabetic nephropathy (accumulation of ECM proteins, progressive proteinuria and albuminuria) at 22 weeks compared with wild-type mice

abnormal renal glomerulus morphology ( J:208963 )

• streptozotocin-treated mice exhibit an attenuated increase in glomerular area and mesangial matrix expansion compared with wild-type mice

abnormal mesangial matrix morphology ( J:208963 )

• streptozotocin-treated mice exhibit an attenuated increase in glomerular area and mesangial matrix expansion compared with wild-type mice

homeostasis/metabolism

abnormal urine protein level ( J:208963 )

• attenuated progressive proteinuria and albuminuria in streptozotocin-treated mice at 22 weeks

decreased physiological sensitivity to xenobiotic ( J:208963 )

• streptozotocin-treated mice exhibit attenuated diabetic nephropathy (accumulation of ECM proteins, progressive proteinuria and albuminuria) at 22 weeks compared with wild-type mice