Phenotypes associated with this allele

• Allele Symbol: Abcc8^tm1.1Fmas
• Allele Name: targeted mutation 1.1, Frances Ashcroft
• Allele ID: MGI:5568409
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Abcc8^tm1.1Fmas/Abcc8^tm1.1Fmas	B6.129S2(Cg)-Abcc8^tm1.1Fmas	MGI:5568494
ht2	Abcc8^tm1.1Fmas/Abcc8^+	B6.129S2(Cg)-Abcc8^tm1.1Fmas	MGI:5568493

Genotype
MGI:5568494

hm1

• Allelic Composition: Abcc8^tm1.1Fmas/Abcc8^tm1.1Fmas
• Genetic Background: B6.129S2(Cg)-Abcc8^tm1.1Fmas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:208932 )

N • mice exhibit normal insulin tolerance

decreased insulin secretion ( J:208932 )

• reduced insulin content in islets at 6 months

• impaired glucose-stimulated insulin secretion

• insulin content does not increase with age unlike wild-type mice

increased insulin secretion ( J:208932 )

• increased basal islet insulin secretion at 8 weeks

• increased insulin content in islets at 6 months

decreased circulating glucose level ( J:208932 )

• in fasting mice at 8 weeks

increased circulating glucose level ( J:208932 )

• slightly in free-fed mice at 2 months

• at 6 months

• however, levels are normal in fasted mice at 2 months

impaired glucose tolerance ( J:208932 )

• at 6 months

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:208932 )

• slight increase in cell size at 2 months

• reduced in K ATP channel activity at 6 months

• increased intracellular calcium levels

• however, beta cell size and number are normal at 6 and 12 months

decreased insulin secretion ( J:208932 )

• impaired glucose-stimulated insulin secretion

• reduced insulin content in islets at 6 months

• insulin content does not increase with age unlike wild-type mice

increased insulin secretion ( J:208932 )

• increased basal islet insulin secretion at 8 weeks

• increased insulin content in islets at 6 months

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hyperinsulinemic hypoglycemia		DOID:13317	OMIM:PS256450	J:208932

Genotype
MGI:5568493

ht2

• Allelic Composition: Abcc8^tm1.1Fmas/Abcc8⁺
• Genetic Background: B6.129S2(Cg)-Abcc8^tm1.1Fmas

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:208932 )

• reduced in K ATP channel activity at 6 months