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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd79atm3(cre/ERT2)Reth
targeted mutation 3, Michael Reth
MGI:5568505
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(ETV6/SYK)Hjum/Gt(ROSA)26Sor+
Cd79atm3(cre/ERT2)Reth/Cd79a+ 		involves: 129S6/SvEvTac * BALB/c MGI:5568507
cn2
 		Gt(ROSA)26Sortm1(ETV6/SYK)Hjum/Gt(ROSA)26Sor+
Cd79atm3(cre/ERT2)Reth/Cd79a+
Tg(BCL2)22Wehi/0 		involves: 129S6/SvEvTac * BALB/c * C57BL/6JWehi * SJL/JWehi MGI:5568509


Genotype
MGI:5568507
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(ETV6/SYK)Hjum/Gt(ROSA)26Sor+
Cd79atm3(cre/ERT2)Reth/Cd79a+
Genetic
Background		 involves: 129S6/SvEvTac * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm3(cre/ERT2)Reth mutation (2 available); any Cd79a mutation (24 available)
Gt(ROSA)26Sortm1(ETV6/SYK)Hjum mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell apoptosis ( J:208904 )
• 20-fold 7 days after tamoxifen-treatment
increased B cell proliferation ( J:208904 )
• in tamoxifen-treated mice
• however, LPS-induced proliferation is normal and treatment with Syk-specific inhibitor R406 abolishes proliferation
enlarged spleen ( J:208904 )
• 3 and 7 days after tamoxifen treatment
• however, spleen size is restored by 14 days post-induction
abnormal plasma cell differentiation ( J:208904 )
• B cells from tamoxifen-treated mice undergo terminal differentiation into short-lived B cells
increased B cell number ( J:208904 )
• CD19+ B cells in tamoxifen-treated mice
• however, the increased numbers is followed by a decrease
increased IgM level ( J:208904 )
• 20-fold 7 days after tamoxifen-treatment
abnormal circulating chemokine level ( J:208904 )
• increased serum levels of monocyte chemoattractant protein-1, peaking at days 3 to 5 after tamoxifen-treatment
increased circulating interferon-gamma level ( J:208904 )
• peaking at days 3 to 5 after tamoxifen-treatment
increased circulating interleukin-10 level ( J:208904 )
• peaking at days 3 to 5 after tamoxifen-treatment
increased circulating interleukin-6 level ( J:208904 )
• peaking at days 3 to 5 after tamoxifen-treatment
increased circulating tumor necrosis factor level ( J:208904 )
• peaking at days 3 to 5 after tamoxifen-treatment
enlarged lymph nodes ( J:208904 )
• 3 and 7 days after tamoxifen treatment
increased interferon-gamma secretion ( J:208904 )
• in follicular B cells after tamoxifen-treatment
increased interleukin-10 secretion ( J:208904 )
• in follicular B cells after tamoxifen-treatment
increased tumor necrosis factor secretion ( J:208904 )
• in follicular B cells after tamoxifen-treatment

homeostasis/metabolism
abnormal circulating chemokine level ( J:208904 )
• increased serum levels of monocyte chemoattractant protein-1, peaking at days 3 to 5 after tamoxifen-treatment
increased circulating interferon-gamma level ( J:208904 )
• peaking at days 3 to 5 after tamoxifen-treatment
increased circulating interleukin-10 level ( J:208904 )
• peaking at days 3 to 5 after tamoxifen-treatment
increased circulating interleukin-6 level ( J:208904 )
• peaking at days 3 to 5 after tamoxifen-treatment
increased circulating tumor necrosis factor level ( J:208904 )
• peaking at days 3 to 5 after tamoxifen-treatment

cellular
increased B cell apoptosis ( J:208904 )
• 20-fold 7 days after tamoxifen-treatment
increased B cell proliferation ( J:208904 )
• in tamoxifen-treated mice
• however, LPS-induced proliferation is normal and treatment with Syk-specific inhibitor R406 abolishes proliferation

hematopoietic system
increased B cell apoptosis ( J:208904 )
• 20-fold 7 days after tamoxifen-treatment
increased B cell proliferation ( J:208904 )
• in tamoxifen-treated mice
• however, LPS-induced proliferation is normal and treatment with Syk-specific inhibitor R406 abolishes proliferation
enlarged spleen ( J:208904 )
• 3 and 7 days after tamoxifen treatment
• however, spleen size is restored by 14 days post-induction
abnormal plasma cell differentiation ( J:208904 )
• B cells from tamoxifen-treated mice undergo terminal differentiation into short-lived B cells
increased B cell number ( J:208904 )
• CD19+ B cells in tamoxifen-treated mice
• however, the increased numbers is followed by a decrease
increased IgM level ( J:208904 )
• 20-fold 7 days after tamoxifen-treatment

growth/size/body
enlarged spleen ( J:208904 )
• 3 and 7 days after tamoxifen treatment
• however, spleen size is restored by 14 days post-induction




Genotype
MGI:5568509
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(ETV6/SYK)Hjum/Gt(ROSA)26Sor+
Cd79atm3(cre/ERT2)Reth/Cd79a+
Tg(BCL2)22Wehi/0
Genetic
Background		 involves: 129S6/SvEvTac * BALB/c * C57BL/6JWehi * SJL/JWehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm3(cre/ERT2)Reth mutation (2 available); any Cd79a mutation (24 available)
Gt(ROSA)26Sortm1(ETV6/SYK)Hjum mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(BCL2)22Wehi mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
enlarged spleen ( J:208904 )
• severe after tamoxifen treatment
abnormal plasma cell differentiation ( J:208904 )
• B cells from tamoxifen-treated mice undergo terminal differentiation into short-lived B cells
abnormal B cell physiology ( J:208904 )
• prolonged survival and reduced apoptosis of plasma cells after tamoxifen treatment
enlarged lymph nodes ( J:208904 )
• severe after tamoxifen treatment

hematopoietic system
enlarged spleen ( J:208904 )
• severe after tamoxifen treatment
abnormal plasma cell differentiation ( J:208904 )
• B cells from tamoxifen-treated mice undergo terminal differentiation into short-lived B cells
abnormal B cell physiology ( J:208904 )
• prolonged survival and reduced apoptosis of plasma cells after tamoxifen treatment

growth/size/body
enlarged spleen ( J:208904 )
• severe after tamoxifen treatment




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory