Phenotypes associated with this allele

• Allele Symbol: Hprt1^{tm4(Tek-IGF1R)Geno}
• Allele Name: targeted mutation 4, Genoway
• Allele ID: MGI:5568544
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Hprt1^tm4(Tek-IGF1R)Geno/Y	B6.129P2-Hprt1^tm4(Tek-IGF1R)Geno	MGI:5568545

Genotype
MGI:5568545

ot1

• Allelic Composition: Hprt1^{tm4(Tek-IGF1R)Geno}/Y
• Genetic Background: B6.129P2-Hprt1^{tm4(Tek-IGF1R)Geno}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:208523 )

♂N • mice exhibit normal aortic relaxation in response to IGF1

♂N • mice exhibit normal arterial blood pressure

abnormal vascular endothelial cell migration ( J:208523 )

♂ • enhanced

abnormal vascular endothelial cell physiology ( J:208523 )

♂ • accelerated endothelial regeneration after arterial injury compared with wild-type cells

increased vasoconstriction ( J:208523 )

♂ • increased constrictor response to phenylephrine

♂ • however, response to acetylcholine and sodium nitroprusside

abnormal vascular wound healing ( J:208523 )

♂ • accelerated endothelial regeneration after arterial injury compared with wild-type cells

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:208523 )

♂N • mice exhibit normal glucose homeostasis

abnormal vascular wound healing ( J:208523 )

♂ • accelerated endothelial regeneration after arterial injury compared with wild-type cells

abnormal nitric oxide homeostasis ( J:208523 )

♂ • mice exhibit reduced insulin-stimulated NOS3 activity and reduced insulin-stimulated NO production in endothelial cells compared with wild-type mice

♂ • however, mice exhibit normal NOS3 activation in response to IGF1

muscle

increased vasoconstriction ( J:208523 )

♂ • increased constrictor response to phenylephrine

♂ • however, response to acetylcholine and sodium nitroprusside

cellular

abnormal vascular endothelial cell migration ( J:208523 )

♂ • enhanced