All Phenotypes Serpina12<tm1Jwada> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Serpina12^tm1Jwada/Serpina12^tm1Jwada	B6JJcl.129P2-Serpina12^tm1Jwada	MGI:5568558
ht2	Serpina12^tm1Jwada/Serpina12⁺	B6JJcl.129P2-Serpina12^tm1Jwada	MGI:5568559

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:208508 )

N	• mice fed a high fat, high sucrose diet exhibit normal adiponectin levels

increased circulating leptin level ( J:208508 )

• at 25 weeks in mice fed a high fat, high sucrose diet

increased circulating cholesterol level ( J:208508 )

• in mice fed a high fat, high sucrose diet

increased circulating LDL cholesterol level ( J:208508 )

• small density LDL in mice fed a high fat, high sucrose diet

insulin resistance ( J:208508 )

• in mice fed a high fat, high sucrose diet

increased liver triglyceride level ( J:208508 )

• in mice fed a high fat, high sucrose diet

adipose tissue

abnormal fat cell morphology ( J:208508 )

• increased crown-like structure in adipocytes of mice fed a high fat, high sucrose diet

increased fat cell size ( J:208508 )

• in mice fed a high fat, high sucrose diet

increased epididymal fat pad weight ( J:208508 )

• in mice fed a high fat, high sucrose diet

growth/size/body

increased body weight ( J:208508 )

• in mice fed a high fat, high sucrose diet

increased liver weight ( J:208508 )

• in mice fed a high fat, high sucrose diet

liver/biliary system

increased liver weight ( J:208508 )

• in mice fed a high fat, high sucrose diet

increased liver triglyceride level ( J:208508 )

• in mice fed a high fat, high sucrose diet

Allelic Composition	Serpina12^tm1Jwada/Serpina12⁺
Genetic Background	B6JJcl.129P2-Serpina12^tm1Jwada

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Serpina12^tm1Jwada mutation (1 available); any Serpina12 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating leptin level ( J:208508 )

• at 25 weeks in mice fed a high fat, high sucrose diet

increased liver triglyceride level ( J:208508 )

• in mice fed a high fat, high sucrose diet

adipose tissue

increased fat cell size ( J:208508 )

• in mice fed a high fat, high sucrose diet

increased epididymal fat pad weight ( J:208508 )

• in mice fed a high fat, high sucrose diet

liver/biliary system

increased liver triglyceride level ( J:208508 )

• in mice fed a high fat, high sucrose diet

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24