Phenotypes associated with this allele

• Allele Symbol: Akr1b7^tm1.1Anm
• Allele Name: targeted mutation 1.1, Antoine Martinez
• Allele ID: MGI:5568561
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Akr1b7^tm1.1Anm/Akr1b7^tm1.1Anm	involves: 129	MGI:5568571

Genotype
MGI:5568571

hm1

• Allelic Composition: Akr1b7^tm1.1Anm/Akr1b7^tm1.1Anm
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:208505 )

N • fasted mice exhibit normal glucose serum levels and glucose tolerance

increased circulating insulin level ( J:208505 )

• basal hyperinsulinemia in mice fed standard chow

increased circulating leptin level ( J:208505 )

• in mice fed standard chow

• 5-fold in mice fed a high fat diet

• however, daily treatment with cloprostenol restores leptin levels

increased circulating glycerol level ( J:208505 )

• in mice fed a high fat diet

• however, fasted mice fed standard chow exhibit normal glycerol levels

increased circulating triglyceride level ( J:208505 )

• in mice fed a high fat diet

decreased energy expenditure ( J:208505 )

• in mice fed standard chow as determined by indirect calorimetry

increased susceptibility to diet-induced obesity ( J:208505 )

• in mice fed a high fat diet

decreased respiratory quotient ( J:208505 )

• in mice fed standard chow

insulin resistance ( J:208505 )

• attenuated response to insulin during insulin tolerance test in mice fed standard chow

• at 6 months in mice fed standard chow

• in mice fed a high fat diet

increased circulating adiponectin level ( J:208505 )

• in mice fed a high fat diet

• however, mice fed standard chow exhibit normal plasma adiponectin levels

increased liver triglyceride level ( J:208505 )

• 2 times in mice fed standard chow

adipose tissue

increased white adipose tissue amount ( J:208505 )

• gonadal, inguinal and periadrenal white adipose tissue in mice fed standard chow

increased white fat cell size ( J:208505 )

• in gonadal, inguinal and periadrenal white adipose tissue in mice fed standard chow

• however, daily treatment with cloprostenol restores fat cell size

increased gonadal fat pad weight ( J:208505 )

• 3 times in mice fed standard chow

• 7.7 times in mice fed a high fat diet

• however, daily treatment with cloprostenol reduces gonadal weight in mice fed a high fat diet

increased inguinal fat pad weight ( J:208505 )

• in mice fed standard chow

abnormal white adipose tissue physiology ( J:208505 )

• increased adipocyte proliferation in mice fed a high fat diet

• however, daily treatment with cloprostenol restores normal adipocyte proliferation

growth/size/body

increased body weight ( J:208505 )

• starting at 7 to 8 weeks in mice fed a standard diet and worsening with time

• in mice fed a high fat diet

increased susceptibility to diet-induced obesity ( J:208505 )

• in mice fed a high fat diet

increased liver weight ( J:208505 )

• in mice fed standard chow

behavior/neurological

behavior/neurological phenotype ( J:208505 )

N • mice fed standard chow exhibit normal food consumption and ambulatory activity

decreased food intake ( J:208505 )

• in mice fed a high fat diet

liver/biliary system

increased liver weight ( J:208505 )

• in mice fed standard chow

increased liver triglyceride level ( J:208505 )

• 2 times in mice fed standard chow

hepatic steatosis ( J:208505 )

• livers accumulate a large amount of lipid droplets in mice fed standard chow

• in mice fed a high fat diet