Phenotypes associated with this allele

• Allele Symbol: Gk5^m1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:5568575
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gk5^m1Btlr/Gk5^m1Btlr	C57BL/6J-Gk5^m1Btlr	MGI:6111856

Genotype
MGI:6111856

hm1

• Allelic Composition: Gk5^m1Btlr/Gk5^m1Btlr
• Genetic Background: C57BL/6J-Gk5^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

integument phenotype ( J:243852 )

N • hair texture and growth

abnormal sebaceous lipid secretion ( J:243852 )

alopecia ( J:243852 )

• dorsal hair loss in first hair cycle

• near total hair loss by age 24 weeks

abnormal hair follicle orientation ( J:243852 )

• more irregular alignment at P10

hair follicle degeneration ( J:243852 )

• start of degeneration of hair bulb at P16

• complete degeneration at P28

abnormal hair cycle ( J:243852 )

• less hair growth during catagen/telogen phase of first hair cycle

• arrested follicular cycling at P21

abnormal hair cycle anagen phase ( J:243852 )

• delayed eruption of hair from the skin surface

abnormal hair cycle catagen phase ( J:243852 )

• less hair growth in first hair cycle

abnormal hair cycle telogen phase ( J:243852 )

• less hair growth in first hair cycle

hyperkeratosis ( J:243852 )

• at P16

epidermal hyperplasia ( J:243852 )

• at P10

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:243852 )

N • circulating cholesterol level

abnormal lipid level ( J:243852 )

• increased in skin

increased cholesterol level ( J:243852 )

• elevated levels of free cholesterol and total cholesteryl esters in skin

abnormal ceramide level ( J:243852 )

• increased in skin

increased triglyceride level ( J:243852 )

• in skin

endocrine/exocrine glands

abnormal sebaceous lipid secretion ( J:243852 )

adipose tissue

decreased white fat cell number ( J:243852 )

• loss of hypodermal adipocytes at P10