All Phenotypes Grb10<tm1.1Fliu> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Grb10^tm1.1Fliu/Grb10^tm1.1Fliu Tg(Fabp4-cre)1Rev/0	involves: 129S/SvEv	MGI:6107174
cn2	Grb10^tm1.1Fliu/Grb10^tm1.1Fliu Tg(Pdx1-cre)6Tuv/0	involves: 129S/SvEv * C57BL/6 * FVB/N	MGI:5569766
cn3	Grb10^tm1.1Fliu/Grb10^tm1.1Fliu Tg(Adipoq-cre)#Pesch/0	involves: 129S/SvEv * FVB	MGI:6107175

Allelic Composition	Grb10^tm1.1Fliu/Grb10^tm1.1Fliu Tg(Fabp4-cre)1Rev/0
Genetic Background	involves: 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb10^tm1.1Fliu mutation (0 available); any Grb10 mutation (56 available)
Tg(Fabp4-cre)1Rev mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased body fat mass ( J:213603 )

• when standard chow despite lean mass

• when fed a high-fat diet despite no increase in food intake

increased brown fat cell size ( J:213603 )

• when fed standard chow or a high-fat diet

whitened brown adipose tissue morphology ( J:213603 )

• brown adipose tissue exhibit larger multilocular lipid droplets compared to in control mice

increased white fat cell size ( J:213603 )

• in epididymal and inguinal white adipose tissues when fed standard chow or a high-fat diet

• however, cell number is normal

abnormal epididymal fat pad morphology ( J:213603 )

• enlarged

growth/size/body

increased body fat mass ( J:213603 )

• when standard chow despite lean mass

• when fed a high-fat diet despite no increase in food intake

increased body weight ( J:213603 )

• at 3 and 6 months

increased susceptibility to age related obesity ( J:213603 )

increased susceptibility to diet-induced obesity ( J:213603 )

• when fed a high-fat diet despite no increase in food intake

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:213603 )

• when fed a high-fat diet despite no increase in food intake

increased circulating insulin level ( J:213603 )

• when fed a high-fat diet

impaired glucose tolerance ( J:213603 )

• when fed a high-fat diet

insulin resistance ( J:213603 )

• when fed a high-fat diet

liver/biliary system

hepatic steatosis ( J:213603 )

• when fed a high-fat diet

Allelic Composition	Grb10^tm1.1Fliu/Grb10^tm1.1Fliu Tg(Pdx1-cre)6Tuv/0
Genetic Background	involves: 129S/SvEv * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb10^tm1.1Fliu mutation (0 available); any Grb10 mutation (56 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:208498 )

N	• mice fed standard chow or a high fat diet exhibit normal insulin tolerance

abnormal glucose homeostasis ( J:208498 )

• in a hyperglycemic clamp study, mice fed standard chow exhibit a higher glucose infusion rate compared with wild-type mice

• mice exhibit reduced STZ-induced hyperglycemic effect compared with wild-type mice

increased insulin secretion ( J:208498 )

• in mice fed standard chow during the hyperglycemic clamp studies

• in STZ-treated mice

decreased circulating glucose level ( J:208498 )

• slightly in fasting mice fed standard chow

• in mice fed a high fat diet

improved glucose tolerance ( J:208498 )

• in mice fed standard chow or a high fat diet

growth/size/body

increased pancreas weight ( J:208498 )

• in mice fed standard chow

• in STZ-treated mice

decreased susceptibility to weight loss ( J:208498 )

• mice exhibit are protected from STZ-induced weight loss compared with wild-type mice

cellular

increased pancreatic beta cell proliferation ( J:208498 )

• in mice fed standard chow

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:208498 )

• beta cells contain increased insulin granules

• however, beta cell size is normal

increased pancreatic beta cell mass ( J:208498 )

• in mice fed standard chow

increased pancreas weight ( J:208498 )

• in mice fed standard chow

• in STZ-treated mice

abnormal pancreatic beta cell physiology ( J:208498 )

• mice are protected from STZ-induced beta cell loss via apoptosis compared with wild-type mice

increased pancreatic beta cell proliferation ( J:208498 )

• in mice fed standard chow

increased insulin secretion ( J:208498 )

• in mice fed standard chow during the hyperglycemic clamp studies

• in STZ-treated mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased body fat mass ( J:213603 )

• at 6 months when fed standard chow despite normal food intake, fasting glucose, bone mineral density and lean mass

• when fed a high-fat diet despite no increase in food intake

• however, rapamycin treatment reduced fat mass

increased brown fat cell size ( J:213603 )

• when fed standard chow or a high-fat diet

• however, cell number is normal and rapamycin treatment reduced cell size

whitened brown adipose tissue morphology ( J:213603 )

• brown adipose tissue exhibit larger multilocular lipid droplets compared to in control mice

• however, rapamycin treatment reduced lipid accumulation in brown adipose tissue

increased white fat cell size ( J:213603 )

• in epididymal and inguinal white adipose tissue when fed standard chow or a high-fat diet

• however, cell number is normal and rapamycin treatment reduced cell size

abnormal epididymal fat pad morphology ( J:213603 )

• enlarged

abnormal interscapular fat pad morphology ( J:213603 )

• increased lipid accumulation

abnormal adipose tissue physiology ( J:213603 )

• reduced beta-adrenoceptor agonist-stimulated glycerol and fatty acid release from brown, inguinal and epididymal fat of fasted mice

abnormal brown adipose tissue physiology ( J:213603 )

• decreased fatty acid oxidation in brown adipocytes

homeostasis/metabolism

decreased fatty acid oxidation ( J:213603 )

• in brown adipocytes

increased susceptibility to diet-induced obesity ( J:213603 )

• when fed a high-fat diet despite no increase in food intake

impaired adaptive thermogenesis ( J:213603 )

• cold-exposed mice exhibit reduced body temperatures compared with control mice

increased circulating insulin level ( J:213603 )

• when fed a high-fat diet

decreased core body temperature ( J:213603 )

• in cold-exposed mice

decreased oxygen consumption ( J:213603 )

• in cold-exposed mice despite normal activity levels and respiratory quotient

impaired glucose tolerance ( J:213603 )

• when fed a high-fat diet

insulin resistance ( J:213603 )

• when fed a high-fat diet

growth/size/body

increased body fat mass ( J:213603 )

• at 6 months when fed standard chow despite normal food intake, fasting glucose, bone mineral density and lean mass

• when fed a high-fat diet despite no increase in food intake

• however, rapamycin treatment reduced fat mass

increased body weight ( J:213603 )

• at 6 months despite normal food intake, fasting glucose, bone mineral density and lean mass

• however, rapamycin treatment reduced body weight gain

increased susceptibility to age related obesity ( J:213603 )

• at 6 months

• however, rapamycin treatment reduced body weight gain

increased susceptibility to diet-induced obesity ( J:213603 )

• when fed a high-fat diet despite no increase in food intake

liver/biliary system

hepatic steatosis ( J:213603 )

• when fed a high-fat diet

cellular

decreased fatty acid oxidation ( J:213603 )

• in brown adipocytes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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