Phenotypes associated with this allele

• Allele Symbol: Sod2^{tm1(rtTA*M2,tetO)Jsg}
• Allele Name: targeted mutation 1, Joel Greenberger
• Allele ID: MGI:5568594
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sod2^tm1(rtTA*M2,tetO)Jsg/Sod2^tm1(rtTA*M2,tetO)Jsg	involves: 129S6/SvEvTac * C57BL/6	MGI:5568705

Genotype
MGI:5568705

hm1

• Allelic Composition: Sod2^{tm1(rtTA*M2,tetO)Jsg}/Sod2^{tm1(rtTA*M2,tetO)Jsg}
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased cellular sensitivity to gamma-irradiation ( J:209713 )

• irradiated bone marrow stromal cell lines generated from homozygous mice exhibit increased radiosensitivity as compared to control cells

increased cell death ( J:209713 )

• bone marrow stromal cell lines generated from homozygous mice exhibit decreased viability 7 days after irradiation as compared to control cells

• total number of cells is decreased 14 days after irradiation as compared to control cells

abnormal double-strand DNA break repair ( J:209713 )

• irradiated bone marrow stromal cell lines generated from homozygous mice exhibit impaired double stranded break repair as compared to control cells

abnormal redox activity ( J:209713 )

• antioxidant stores are significantly increased in irradiated bone marrow stromal cell lines incubated with doxycycline as compared to irradiated wild-type cell lines

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:209713 )

• irradiated bone marrow stromal cell lines generated from homozygous mice exhibit impaired double stranded break repair as compared to control cells