Phenotypes associated with this allele

• Allele Symbol: Tnfrsf9^em1Ygch
• Allele Name: endonuclease-mediated mutation 1, Yi-Guang Chen
• Allele ID: MGI:5568599
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnfrsf9^em1Ygch/Tnfrsf9^em1Ygch	NOD/ShiLtDvs-Tnfrsf9^em1Ygch	MGI:5568605

Genotype
MGI:5568605

hm1

• Allelic Composition: Tnfrsf9^em1Ygch/Tnfrsf9^em1Ygch
• Genetic Background: NOD/ShiLtDvs-Tnfrsf9^em1Ygch

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:208927 )

♀N • mice exhibit normal numbers of CD4 and CD8 T cells, B cells, NK cells and myeloid cells

insulitis ( J:208927 )

♀ • severe in non-diabetic female mice at 30, but not 10, weeks

abnormal T cell physiology ( J:208927 )

♀ • T cells exhibit reduced ability to induce Type 1 diabetes when transferred into Rag1 deficient mice compared with control T cell from NOD mice

homeostasis/metabolism

abnormal glucose homeostasis ( J:208927 )

♀ • female mice exhibit later onset of Type 1 diabetes compared with wild-type NOD mice

endocrine/exocrine glands

insulitis ( J:208927 )

♀ • severe in non-diabetic female mice at 30, but not 10, weeks

hematopoietic system

abnormal T cell physiology ( J:208927 )

♀ • T cells exhibit reduced ability to induce Type 1 diabetes when transferred into Rag1 deficient mice compared with control T cell from NOD mice