Phenotypes associated with this allele

• Allele Symbol: Gys2^tm1.1Arte
• Allele Name: targeted mutation 1.1, TaconicArtemis
• Allele ID: MGI:5568615
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gys2^tm1.1Arte/Gys2^tm1.1Arte	Not Specified	MGI:5568699
ht2	Gys2^tm1.1Arte/Gys2^+	Not Specified	MGI:5568698

Genotype
MGI:5568699

hm1

• Allelic Composition: Gys2^tm1.1Arte/Gys2^tm1.1Arte
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:208923 )

• increased glucose oxidation

• hepatocytes exhibit altered glucose flux favoring lipogenesis

• during euglycemic-hyperinsulinemic clamp, mice exhibit reduced rate of glucose disposal and glucose clearance compared with wild-type mice

decreased circulating glucose level ( J:208923 )

• after a short fast

• however, levels are normal in fed and long fasted mice

decreased circulating insulin level ( J:208923 )

• basal levels

• however, level under euglycemic-hyperinsulinemic clamp is normal

abnormal gluconeogenesis ( J:208923 )

• impaired basal production

• however, mice exhibit normal suppression of glucose synthesis during the clamp

impaired glucose tolerance ( J:208923 )

decreased glycogen catabolism rate ( J:208923 )

• in hepatocytes stimulated with insulin or CpdA

• impaired glycogen synthesis after glucose administration or refeeding

decreased liver glycogen level ( J:208923 )

• near absence

insulin resistance ( J:208923 )

• modest during the euglycemic-hyperinsulinemic clamp

increased liver triglyceride level ( J:208923 )

• at 2 to 3 months

• at 6 months

liver/biliary system

decreased liver glycogen level ( J:208923 )

• near absence

increased liver triglyceride level ( J:208923 )

• at 2 to 3 months

• at 6 months

abnormal hepatocyte physiology ( J:208923 )

• hepatocytes exhibit altered glucose flux favoring lipogenesis

• absence of glycogen synthesis after glucose administration or refeeding

Genotype
MGI:5568698

ht2

• Allelic Composition: Gys2^tm1.1Arte/Gys2⁺
• Genetic Background: Not Specified

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:208923 )

N • mice exhibit normal whole-body insulin sensitivity

impaired glucose tolerance ( J:208923 )

decreased glycogen catabolism rate ( J:208923 )

• stimulated by CpdA

• however, insulin stimulated incorporation of labeled glucose into glycogen

increased liver triglyceride level ( J:208923 )

• at 6 months

liver/biliary system

increased liver triglyceride level ( J:208923 )

• at 6 months

abnormal hepatocyte physiology ( J:208923 )

• impaired glycogen synthesis after glucose administration or refeeding