Phenotypes associated with this allele

• Allele Symbol: Pde10a^tm1Smsh
• Allele Name: targeted mutation 1, Sean M Smith
• Allele ID: MGI:5568702
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pde10a^tm1Smsh/Pde10a^tm1Smsh	B6NTac.Cg-Pde10a^tm1Smsh	MGI:5568713

Genotype
MGI:5568713

hm1

• Allelic Composition: Pde10a^tm1Smsh/Pde10a^tm1Smsh
• Genetic Background: B6NTac.Cg-Pde10a^tm1Smsh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:209032 )

• in mice fed a high fat diet

abnormal circulating glucose level ( J:209032 )

• mice fed a high fat diet exhibit normalized serum glucose level compared with wild-type mice

abnormal circulating insulin level ( J:209032 )

• mice fed a high fat diet exhibit normalized serum insulin level compared with wild-type mice

decreased circulating insulin level ( J:209032 )

• in mice fed a high fat diet

decreased circulating leptin level ( J:209032 )

• in mice fed a high fat diet

decreased circulating cholesterol level ( J:209032 )

• in mice fed a high fat diet

decreased circulating alanine transaminase level ( J:209032 )

• in mice fed a high fat diet

decreased respiratory quotient ( J:209032 )

• in mice fed a high fat diet

increased insulin sensitivity ( J:209032 )

• in mice fed a high fat diet

growth/size/body

decreased lean body mass ( J:209032 )

• in mice fed a high fat diet

decreased body weight ( J:209032 )

• in mice fed a high fat diet

decreased susceptibility to diet-induced obesity ( J:209032 )

• in mice fed a high fat diet

behavior/neurological

decreased food intake ( J:209032 )

• overall and within 30 minutes, in mice fed a high fat diet

• however, food intake is normal in mice fed normal chow

adipose tissue

decreased total fat pad weight ( J:209032 )

• in mice fed a high fat diet