Phenotypes associated with this allele

• Allele Symbol: Il9^tm1Flv
• Allele Name: targeted mutation 1, Richard A Flavell
• Allele ID: MGI:5568753
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il9^tm1Flv/Il9^tm1Flv	BALB/c-Il9^tm1Flv	MGI:5568838

Genotype
MGI:5568838

hm1

• Allelic Composition: Il9^tm1Flv/Il9^tm1Flv
• Genetic Background: BALB/c-Il9^tm1Flv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to parasitic infection ( J:208730 )

• mice infected with N. brasiliensis exhibit higher worm burden, reduced eosinophils and basophils in the lungs, mesenteric lymph nodes and spleen, reduced mast cells in the lung, mesenteric lymph nodes and spleen, and reduced absolute cells in the spleen and mediastinal lymph nodes compared with wild-type mice

• however, infected mice exhibit normal absolute cell numbers in the mesenteric lymph nodes and lungs and mast cell numbers in mediastinal lymph nodes

• however, treatment with Th9 cells partially rescues phenotypes