Phenotypes associated with this allele

• Allele Symbol: Pip4k2a^tm1.2Lca
• Allele Name: targeted mutation 1.2, Lewis C Cantley
• Allele ID: MGI:5568930
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pip4k2a^tm1.2Lca/Pip4k2a^tm1.2Lca	involves: 129S/SvEv	MGI:5568931
cx2	Pip4k2a^tm1.2Lca/Pip4k2a^tm1.2Lca Pip4k2b^Gt(Betageo)1Lca/Pip4k2b^+ Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S/SvEv * 129S2/SvPas * 129S5/SvEvBrd	MGI:5568940
cx3	Pip4k2a^tm1.2Lca/Pip4k2a^tm1.2Lca Pip4k2b^Gt(Betageo)1Lca/Pip4k2b^Gt(Betageo)1Lca	involves: 129S/SvEv * 129S5/SvEvBrd	MGI:5568937
cx4	Pip4k2a^tm1.2Lca/Pip4k2a^+ Pip4k2b^Gt(Betageo)1Lca/Pip4k2b^Gt(Betageo)1Lca	involves: 129S/SvEv * 129S5/SvEvBrd	MGI:5568938

Genotype
MGI:5568931

hm1

• Allelic Composition: Pip4k2a^tm1.2Lca/Pip4k2a^tm1.2Lca
• Genetic Background: involves: 129S/SvEv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:205288 )

• mice are born near Mendelian ratios and show no obvious histological, growth or reproductive phenotypes

Genotype
MGI:5568940

cx2

• Allelic Composition: Pip4k2a^tm1.2Lca/Pip4k2a^tm1.2Lca; Pip4k2b^{Gt(Betageo)1Lca}/Pip4k2b⁺; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129S/SvEv * 129S2/SvPas * 129S5/SvEvBrd

neoplasm

decreased tumor incidence ( J:205288 )

• mice show a dramatic reduction in tumor formation and increased survival compared to single Trp53 homozygotes

Genotype
MGI:5568937

cx3

• Allelic Composition: Pip4k2a^tm1.2Lca/Pip4k2a^tm1.2Lca; Pip4k2b^{Gt(Betageo)1Lca}/Pip4k2b^{Gt(Betageo)1Lca}
• Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd

mortality/aging

neonatal lethality, complete penetrance ( J:205288 )

• pups look normal at birth and are able to suckle, but die within 12 hours of birth

Genotype
MGI:5568938

cx4

• Allelic Composition: Pip4k2a^tm1.2Lca/Pip4k2a⁺; Pip4k2b^{Gt(Betageo)1Lca}/Pip4k2b^{Gt(Betageo)1Lca}
• Genetic Background: involves: 129S/SvEv * 129S5/SvEvBrd

mortality/aging

neonatal lethality, incomplete penetrance ( J:205288 )

• mice are born at Mendelian ratios with normal appearance and weight, however about half die within 12 hours after birth

growth/size/body

decreased body weight ( J:205288 )

• surviving adults are only 50% the weight of wild-type mice

postnatal growth retardation ( J:205288 )

• surviving mice are growth retarded