Phenotypes associated with this allele

• Allele Symbol: Hspb1^tm1.1Jdn
• Allele Name: targeted mutation 1.1, Jonathan Dean
• Allele ID: MGI:5568935
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hspb1^tm1.1Jdn/Hspb1^tm1.1Jdn	B6.129S2(Cg)-Hspb1^tm1.1Jdn	MGI:5568950

Genotype
MGI:5568950

hm1

• Allelic Composition: Hspb1^tm1.1Jdn/Hspb1^tm1.1Jdn
• Genetic Background: B6.129S2(Cg)-Hspb1^tm1.1Jdn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Reduced re-epithelialisation, impaired collagen deposition and increased cellular infiltration in Hspb1^tm1.1Jdn/Hspb1^tm1.1Jdn wounds

immune system

abnormal neutrophil physiology ( J:209117 )

• increased neutrophil infiltration in biopsy punch wound granulation tissue despite normal numbers of circulating neutrophils

• increased neutrophil infiltration in the air-pouch model of zymosan-induced inflammation

abnormal macrophage physiology ( J:209117 )

• slightly decreased macrophage infiltration in biopsy punch wound granulation tissue

abnormal chemokine secretion ( J:209117 )

• increased CXCL1 and CCL2 early in the wound healing process, in the air-pouch model of mice treated with zymogen and in the zymogen-induced model of peritonitis

increased interleukin-6 secretion ( J:209117 )

• in mouse embryonic fibroblasts treated with IL1

• early in the wound healing process

increased inflammatory response ( J:209117 )

• in the zymogen-induced model of peritonitis

homeostasis/metabolism

abnormal wound healing ( J:209117 )

• biopsy punch wounds exhibit reduced collagen deposition and re-epithelialization but increased cellular infiltration compared with wounds in wild-type mice

delayed wound healing ( J:209117 )

• delayed wound healing with larger wound areas 1.6-fold, 2.9-fold and 2.2-fold at days 3, 5 and 7 after biopsy punch

impaired wound healing ( J:209117 )

• after biopsy punch, mice exhibit delayed wound healing with larger wound areas 1.6-fold, 2.9-fold and 2.2-fold at days 3, 5 and 7, delayed re-epithelialization, increased neutrophil infiltration but slightly decreased macrophage infiltration in wound granulation tissue and increased early chemokine and cytokine expression compared with wild-type mice

cellular

abnormal cell cycle ( J:209117 )

• mouse embryonic fibroblasts exhibit reduced entry into S phase compared with wild-type cells

decreased fibroblast proliferation ( J:209117 )

• in mouse embryonic fibroblasts

hematopoietic system

abnormal neutrophil physiology ( J:209117 )

• increased neutrophil infiltration in biopsy punch wound granulation tissue despite normal numbers of circulating neutrophils

• increased neutrophil infiltration in the air-pouch model of zymosan-induced inflammation

abnormal macrophage physiology ( J:209117 )

• slightly decreased macrophage infiltration in biopsy punch wound granulation tissue