All Phenotypes Khdrbs2<tm1.1Schei> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Khdrbs2^tm1.1Schei
targeted mutation 1.1, Peter Scheiffele
MGI:5568964

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Khdrbs2^tm1.1Schei/Khdrbs2^tm1.1Schei	involves: 129S6/SvEvTac * BALB/cJ	MGI:5568965
cx2	Khdrbs1^tm1Rchd/Khdrbs1^tm1Rchd Khdrbs2^tm1.1Schei/Khdrbs2^tm1.1Schei	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * BALB/cJ	MGI:5568966

Allelic Composition	Khdrbs2^tm1.1Schei/Khdrbs2^tm1.1Schei
Genetic Background	involves: 129S6/SvEvTac * BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Khdrbs2^tm1.1Schei mutation (1 available); any Khdrbs2 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

small cerebellum ( J:208331 )

• reduced cerebellum weight

Allelic Composition	Khdrbs1^tm1Rchd/Khdrbs1^tm1Rchd Khdrbs2^tm1.1Schei/Khdrbs2^tm1.1Schei
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Khdrbs1^tm1Rchd mutation (1 available); any Khdrbs1 mutation (33 available)
Khdrbs2^tm1.1Schei mutation (1 available); any Khdrbs2 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

infertility ( J:208331 )

nervous system

reduced cerebellar foliation ( J:208331 )

• loss of fissure separating lobules VIb and VII

decreased brain size ( J:208331 )

delaminated Purkinje cell layer ( J:208331 )

• disorganized layer within the fused region of lobules VIb and VII

small cerebellum ( J:208331 )

• reduced cerebellum weight

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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