Phenotypes associated with this allele

• Allele Symbol: Usp21^tm1.1Jhy
• Allele Name: targeted mutation 1.1, Jianhua Yang
• Allele ID: MGI:5568976
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Usp21^tm1.1Jhy/Usp21^tm1.1Jhy	B6.129S7(Cg)-Usp21^tm1.1Jhy	MGI:5568977

Genotype
MGI:5568977

hm1

• Allelic Composition: Usp21^tm1.1Jhy/Usp21^tm1.1Jhy
• Genetic Background: B6.129S7(Cg)-Usp21^tm1.1Jhy

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:208320 )

• after VSV infection in mutants or hosts with mutant bone marrow cells

hematopoietic system

hematopoietic system phenotype ( J:208320 )

N • similar thymus size

enlarged spleen ( J:208320 )

• after two weeks of VSV-infection in mutants or hosts with mutant bone marrow cells

increased spleen weight ( J:208320 )

• at 9 weeks of age

increased neutrophil cell number ( J:208320 )

• in the spleen

increased macrophage cell number ( J:208320 )

• in the spleen

increased splenocyte number ( J:208320 )

• at 9 weeks of age

• increase number of macrophages and neutrophils in the spleen

immune system

enlarged spleen ( J:208320 )

• after two weeks of VSV-infection in mutants or hosts with mutant bone marrow cells

increased spleen weight ( J:208320 )

• at 9 weeks of age

increased neutrophil cell number ( J:208320 )

• in the spleen

increased macrophage cell number ( J:208320 )

• in the spleen

increased splenocyte number ( J:208320 )

• at 9 weeks of age

• increase number of macrophages and neutrophils in the spleen

abnormal interferon level ( J:208320 )

• higher SeV infection-induced interferon-alpha/beta production in peritoneal macrophage and bone marrow derived-dendritic cell

• higher Sendai virus (SeV) infection-, poly(I:C)-, and RIG-I-CARD-induced interferon-alpha and -beta activities in mouse embryonic fibroblasts

increased circulating interferon-alpha level ( J:208320 )

• in mutants with intravenous or intraperitoneal infection of vesicular stomatitis virus (VSV)

increased circulating interferon-beta level ( J:208320 )

• in mutants with intravenous or intraperitoneal infection of VSV

decreased susceptibility to Riboviria infection ( J:208320 )

• in mouse embryonic fibroblasts when infected with VSV-eGFP

decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:208320 )

• after VSV infection in mutants or hosts with mutant bone marrow cells

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:208320 )

N • normal basal interferon level at 9 weeks of age

abnormal interferon level ( J:208320 )

• higher SeV infection-induced interferon-alpha/beta production in peritoneal macrophage and bone marrow derived-dendritic cell

• higher Sendai virus (SeV) infection-, poly(I:C)-, and RIG-I-CARD-induced interferon-alpha and -beta activities in mouse embryonic fibroblasts

increased circulating interferon-alpha level ( J:208320 )

• in mutants with intravenous or intraperitoneal infection of vesicular stomatitis virus (VSV)

increased circulating interferon-beta level ( J:208320 )

• in mutants with intravenous or intraperitoneal infection of VSV

growth/size/body

enlarged spleen ( J:208320 )

• after two weeks of VSV-infection in mutants or hosts with mutant bone marrow cells

increased spleen weight ( J:208320 )

• at 9 weeks of age