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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sh2b1tm2.1Lr
targeted mutation 2.1, Liangyou Rui
MGI:5568997
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Sh2b1tm2.1Lr/Sh2b1tm2.1Lr
Tg(Pdx1-cre)89.1Dam/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL MGI:5569100


Genotype
MGI:5569100
cn1
Allelic
Composition
Sh2b1tm2.1Lr/Sh2b1tm2.1Lr
Tg(Pdx1-cre)89.1Dam/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2b1tm2.1Lr mutation (0 available); any Sh2b1 mutation (49 available)
Tg(Pdx1-cre)89.1Dam mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• mice fed standard chow exhibit normal blood glucose levels, glucose tolerance and insulin sensitivity
• stimulated by glucose in mice fed a high fat diet
• reduced pancreatic insulin content in mice fed a high fat diet treated with STZ
• in mice treated with STZ
• in mice treated with STZ
• in mice fed a high fat diet
• however, mice fed standard chow exhibit normal glucose tolerance

endocrine/exocrine glands
• in mice fed a high fat diet
• decreased individual islet size and total islet area in mice fed a high fat diet
• increased beta cell apoptosis in mice fed a high fat diet
• beta cells exhibit increased sensitivity to cytokine-induced cell death compared with wild-type cells
• in mice fed a high fat diet
• stimulated by glucose in mice fed a high fat diet
• reduced pancreatic insulin content in mice fed a high fat diet treated with STZ

cellular
• in mice fed a high fat diet





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory