Phenotypes associated with this allele

• Allele Symbol: Bcs1l^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5569046
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bcs1l^tm1.1(KOMP)Vlcg/Bcs1l^tm1.1(KOMP)Vlcg	C57BL/6N-Bcs1l^tm1.1(KOMP)Vlcg/Mmucd	MGI:6261970

Genotype
MGI:6261970

hm1

• Allelic Composition: Bcs1l^{tm1.1(KOMP)Vlcg}/Bcs1l^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Bcs1l^{tm1.1(KOMP)Vlcg}/Mmucd
• Cell Lines: 10590A-B8

Data Sources

IMPC Data for Bcs1l

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Bcs1l^{tm1.1(KOMP)Vlcg}/Bcs1l^{tm1.1(KOMP)Vlcg} mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos are smaller and form a rudimentary egg cylinder but no primitive streak or hallmarks of gastrulation are seen at E7.5.

embryo

failure to gastrulate ( J:290315 , J:279207 )

• no morphological hallmarks typical of gastrulating embryos are observed at E7.5 (J:279207)

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

decreased egg cylinder size ( J:279207 )

• a rudimentary egg cylinder is observed at E7.5

absent head fold ( J:279207 )

• no head folds are present at E7.5

absent primitive node ( J:279207 )

• no embryonic node is present at E7.5

failure of primitive streak formation ( J:279207 )

• no morphological evidence of primitive streak formation is observed at E7.5

growth/size/body

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - UCD

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - UCD

embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )

• homozygous embryos are present in expected Mendelian ratios at E7.5; no homozygous embryos are recovered at E9.5

preweaning lethality, complete penetrance ( J:211773 )

IMPC - UCD