Phenotypes associated with this allele

• Allele Symbol: Frey1^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5569048
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Frey1^tm1.1(KOMP)Vlcg/Frey1^tm1.1(KOMP)Vlcg	C57BL/6N-Frey1^tm1.1(KOMP)Vlcg/Mmucd	MGI:6261742
hm2	Frey1^tm1.1(KOMP)Vlcg/Frey1^tm1.1(KOMP)Vlcg	C57BL/6NTac-Frey1^tm1.1(KOMP)Vlcg	MGI:7385108
cx3	Frey1^tm1.1(KOMP)Vlcg/Frey1^tm1.1(KOMP)Vlcg Sppl2c^tm1.1(KOMP)Vlcg/Sppl2c^tm1.1(KOMP)Vlcg	C57BL/6NTac-Frey1^tm1.1(KOMP)Vlcg Sppl2c^tm1.1(KOMP)Vlcg	MGI:7385112

Genotype
MGI:6261742

hm1

• Allelic Composition: Frey1^{tm1.1(KOMP)Vlcg}/Frey1^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Frey1^{tm1.1(KOMP)Vlcg}/Mmucd
• Cell Lines: 10173B-A2

Data Sources

IMPC Data for Frey1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating creatinine level ( J:211773 )

♂

IMPC - UCD

decreased circulating phosphate level ( J:211773 )

♂

IMPC - UCD

integument

abnormal skin morphology ( J:211773 )

♀

IMPC - UCD

reproductive system

male infertility ( J:211773 )

♂

IMPC - UCD

Genotype
MGI:7385108

hm2

• Allelic Composition: Frey1^{tm1.1(KOMP)Vlcg}/Frey1^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6NTac-Frey1^{tm1.1(KOMP)Vlcg}

reproductive system

reproductive system phenotype ( J:328498 )

N • sperm exhibit normal morphology and motility

male infertility ( J:328498 )

failure of sperm-egg fusion ( J:328498 )

decreased fertilization frequency ( J:328498 )

• however, sperm are capable of binding oocytes

Genotype
MGI:7385112

cx3

• Allelic Composition: Frey1^{tm1.1(KOMP)Vlcg}/Frey1^{tm1.1(KOMP)Vlcg}; Sppl2c^{tm1.1(KOMP)Vlcg}/Sppl2c^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6NTac-Frey1^{tm1.1(KOMP)Vlcg} Sppl2c^{tm1.1(KOMP)Vlcg}

reproductive system

male infertility ( J:328498 )