Phenotypes associated with this allele

• Allele Symbol: Cul5^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5569059
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cul5^tm1.1(KOMP)Vlcg/Cul5^tm1.1(KOMP)Vlcg	C57BL/6N-Cul5^tm1.1(KOMP)Vlcg/Ucd	MGI:6262227
hm2	Cul5^tm1.1(KOMP)Vlcg/Cul5^tm1.1(KOMP)Vlcg	involves: C57BL/6NTac	MGI:6118146
ht3	Cul5^tm1.1(KOMP)Vlcg/Cul5^+	C57BL/6N-Cul5^tm1.1(KOMP)Vlcg/Ucd	MGI:6262226
ht4	Cul5^tm1.1(KOMP)Vlcg/Cul5^+	involves: C57BL/6NTac	MGI:6118147

Genotype
MGI:6262227

hm1

• Allelic Composition: Cul5^{tm1.1(KOMP)Vlcg}/Cul5^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Cul5^{tm1.1(KOMP)Vlcg}/Ucd
• Cell Lines: 15150A-D10

Data Sources

IMPC Data for Cul5

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal pericardium morphology ( J:211773 )

♀

IMPC - UCD

embryo

embryonic growth retardation ( J:211773 )

♀

IMPC - UCD

abnormal embryo size ( J:211773 )

♀

IMPC - UCD

abnormal neural tube morphology ( J:211773 )

♀

IMPC - UCD

growth/size/body

embryonic growth retardation ( J:211773 )

♀

IMPC - UCD

abnormal embryo size ( J:211773 )

♀

IMPC - UCD

integument

pallor ( J:211773 )

♀

IMPC - UCD

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - UCD

preweaning lethality, complete penetrance ( J:211773 )

IMPC - UCD

nervous system

abnormal neural tube morphology ( J:211773 )

♀

IMPC - UCD

Genotype
MGI:6118146

hm2

• Allelic Composition: Cul5^{tm1.1(KOMP)Vlcg}/Cul5^{tm1.1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac
• Cell Lines: 15150A-D10

mortality/aging

embryonic lethality, complete penetrance ( J:244502 )

Genotype
MGI:6262226

ht3

• Allelic Composition: Cul5^{tm1.1(KOMP)Vlcg}/Cul5⁺
• Genetic Background: C57BL/6N-Cul5^{tm1.1(KOMP)Vlcg}/Ucd
• Cell Lines: 15150A-D10

Data Sources

IMPC Data for Cul5

cardiovascular system

abnormal heart morphology ( J:211773 )

♂

IMPC - UCD

enlarged heart ( J:211773 )

♂

IMPC - UCD

growth/size/body

enlarged heart ( J:211773 )

♂

IMPC - UCD

enlarged spleen ( J:211773 )

♂

IMPC - UCD

increased spleen weight ( J:211773 )

♂

IMPC - UCD

hematopoietic system

abnormal spleen morphology ( J:211773 )

♂

IMPC - UCD

enlarged spleen ( J:211773 )

♂

IMPC - UCD

increased spleen weight ( J:211773 )

♂

IMPC - UCD

immune system

abnormal spleen morphology ( J:211773 )

♂

IMPC - UCD

enlarged spleen ( J:211773 )

♂

IMPC - UCD

increased spleen weight ( J:211773 )

♂

IMPC - UCD

Genotype
MGI:6118147

ht4

• Allelic Composition: Cul5^{tm1.1(KOMP)Vlcg}/Cul5⁺
• Genetic Background: involves: C57BL/6NTac
• Cell Lines: 15150A-D10

immune system

decreased interleukin-1 alpha secretion ( J:244502 )

• in bronchoalveolar fluid of LPS-treated mice

• from splenocytes stimulated with LPS

decreased interleukin-6 secretion ( J:244502 )

• in bronchoalveolar fluid of LPS-treated mice

• from alveolar and peritoneal macrophages, but not splenocytes, stimulated with LPS

decreased tumor necrosis factor secretion ( J:244502 )

• in bronchoalveolar fluid of LPS-treated mice

• from alveolar and peritoneal macrophages stimulated with LPS

homeostasis/metabolism

decreased susceptibility to injury ( J:244502 )

• reduced lung injury after LPS treatment with reduced neutrophil infiltration, total protein concentration and total cell number in bronchoalveolar fluid and concentrations of IL1beta, IL6 and TNFalpha

• however, adoptive transfer of wild-type peritoneal macrophages restores normal susceptibility