Phenotypes associated with this allele

• Allele Symbol: Cyren^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5569061
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cyren^tm1.1(KOMP)Vlcg/Cyren^tm1.1(KOMP)Vlcg	C57BL/6N-Cyren^tm1.1(KOMP)Vlcg/Ucd	MGI:5797318
hm2	Cyren^tm1.1(KOMP)Vlcg/Cyren^tm1.1(KOMP)Vlcg	involves: C57BL/6NTac	MGI:6400577
cx3	Cyren^tm1.1(KOMP)Vlcg/Cyren^tm1.1(KOMP)Vlcg Nhej1^tm1Fwa/Nhej1^tm1Fwa	involves: 129S6/SvEvTac * C57BL/6NTac	MGI:6400579

Genotype
MGI:5797318

hm1

• Allelic Composition: Cyren^{tm1.1(KOMP)Vlcg}/Cyren^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Cyren^{tm1.1(KOMP)Vlcg}/Ucd
• Cell Lines: 12667B-H5

Data Sources

IMPC Data for Cyren

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal heart morphology ( J:211773 )

♂

IMPC - UCD

enlarged heart ( J:211773 )

♂

IMPC - UCD

endocrine/exocrine glands

abnormal testis morphology ( J:211773 )

♂

IMPC - UCD

small testis ( J:211773 )

♂

IMPC - UCD

growth/size/body

enlarged heart ( J:211773 )

♂

IMPC - UCD

reproductive system

abnormal testis morphology ( J:211773 )

♂

IMPC - UCD

small testis ( J:211773 )

♂

IMPC - UCD

Genotype
MGI:6400577

hm2

• Allelic Composition: Cyren^{tm1.1(KOMP)Vlcg}/Cyren^{tm1.1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac

cellular

increased cellular sensitivity to ionizing radiation ( J:265834 )

• increased sensitivity of MEFs to infrared (IR) laser-induced DNA damage

hematopoietic system

abnormal class switch recombination ( J:265834 )

• defects in nave splenic B cell Ig CSR in vitro

• normal development of bone marrow B cells

immune system

abnormal class switch recombination ( J:265834 )

• defects in nave splenic B cell Ig CSR in vitro

• normal development of bone marrow B cells

Genotype
MGI:6400579

cx3

• Allelic Composition: Cyren^{tm1.1(KOMP)Vlcg}/Cyren^{tm1.1(KOMP)Vlcg}; Nhej1^tm1Fwa/Nhej1^tm1Fwa
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

cellular

increased neuron apoptosis ( J:265834 )

• widespread neuronal apoptosis within cortex and ganglionic eminences at age E14.5-16.5

growth/size/body

decreased fetal size ( J:265834 )

• significantly reduced embryo size at age E14.5-16.5

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:265834 )

• no mice born

• significantly reduced embryo size at age E14.5-16.5

• normal Mendelian ratio at age E14.5-16.5

nervous system

increased neuron apoptosis ( J:265834 )

• widespread neuronal apoptosis within cortex and ganglionic eminences at age E14.5-16.5