Phenotypes associated with this allele

• Allele Symbol: Drd5^tm1Shay
• Allele Name: targeted mutation 1, Seiji Hayashizaki
• Allele ID: MGI:5569103
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Drd5^tm1Shay/Drd5^tm1Shay	B6.129P2-Drd5^tm1Shay	MGI:5569104

Genotype
MGI:5569104

hm1

• Allelic Composition: Drd5^tm1Shay/Drd5^tm1Shay
• Genetic Background: B6.129P2-Drd5^tm1Shay

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:209099 )

N • mice exhibit normal cocaine-induced ambulation

enhanced behavioral response to methamphetamine ( J:209099 )

• mice exhibit increased methamphetamine-induced ambulatory activity

• however, pre-treatment with the dopamine transporter blocker GBR12909 eliminates methamphetamine-induced hyperlocomotor activity

nervous system

nervous system phenotype ( J:209099 )

N • mice exhibit normal methamphetamine-induced dopamine transmission