All Phenotypes Dcbld2<tm1.1Mhms> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dcbld2^tm1.1Mhms
targeted mutation 1.1, Mehran M Sadeghi
MGI:5569304

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dcbld2^tm1.1Mhms/Dcbld2^tm1.1Mhms	B6.129S6-Dcbld2^tm1.1Mhms	MGI:5569329
cn2	Dcbld2^tm1Mhms/Dcbld2^tm1.1Mhms Tg(Cdh5-cre)7Mlia/0	involves: 129S6/SvEvTac * C57BL/6J * FVB/N	MGI:5569330

Allelic Composition	Dcbld2^tm1.1Mhms/Dcbld2^tm1.1Mhms
Genetic Background	B6.129S6-Dcbld2^tm1.1Mhms

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dcbld2^tm1.1Mhms mutation (0 available); any Dcbld2 mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Attenuation of adult angiogenesis following left femoral artery ligation in Dcbld2^tm1.1Mhms/Dcbld2^tm1.1Mhms mice

cardiovascular system

abnormal retina vasculature morphology ( J:207629 )

• at P5, retinal blood vessels exhibit reduced total length and number of branches compared to in wild-type mice

abnormal pericyte morphology ( J:207629 )

• reduced pericyte staining

decreased angiogenesis ( J:207629 )

• at P5, retinal blood vessels exhibit reduced total length and number of branches compared to in wild-type mice

• reduced increase in capillary density of adult mice following femoral artery ligation

abnormal blood flow velocity ( J:207629 )

• impaired blood flow recovery following femoral artery ligation

respiratory system

decreased lung endothelial cell migration ( J:207629 )

• induced by VEGF

decreased lung endothelial cell proliferation ( J:207629 )

• induced by VEGF

vision/eye

abnormal retina vasculature morphology ( J:207629 )

• at P5, retinal blood vessels exhibit reduced total length and number of branches compared to in wild-type mice

cellular

decreased lung endothelial cell migration ( J:207629 )

• induced by VEGF

decreased lung endothelial cell proliferation ( J:207629 )

• induced by VEGF

Allelic Composition	Dcbld2^tm1Mhms/Dcbld2^tm1.1Mhms Tg(Cdh5-cre)7Mlia/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dcbld2^tm1.1Mhms mutation (0 available); any Dcbld2 mutation (48 available)
Dcbld2^tm1Mhms mutation (0 available); any Dcbld2 mutation (48 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Decreased retinal angiogenesis in Dcbld2^tm1Mhms/Dcbld2^tm1.1Mhms Tg(Cdh5-cre)7Mlia/0 mice

cardiovascular system

abnormal retina vasculature morphology ( J:207629 )

• at P5, retinal blood vessels exhibit reduced total length and number of branches compared to in wild-type mice

abnormal pericyte morphology ( J:207629 )

• reduced pericyte staining

decreased angiogenesis ( J:207629 )

• at P5, retinal blood vessels exhibit reduced total length and number of branches compared to in wild-type mice

vision/eye

abnormal retina vasculature morphology ( J:207629 )

• at P5, retinal blood vessels exhibit reduced total length and number of branches compared to in wild-type mice

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