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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sryem1Takas
endonuclease-mediated mutation 1, Shuji Takada
MGI:5569481
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ot1
 		X/Sryem1Takas involves: C57BL/6 * DBA/2 MGI:5569485


Genotype
MGI:5569485
ot1
Allelic
Composition		 X/Sryem1Takas
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sryem1Takas mutation (0 available); any Sry mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal ovarian follicle morphology ( J:207780 )
• mice exhibit luteinized unruptured follicles, including oocytes retained in the corpus luteum, unlike wild-type mice
primary sex reversal ( J:207780 )
• XY individuals with female external genitalia, nipples and internal genitalia
prolonged estrus ( J:207780 )
• a little longer than in wild-type female mice
• however, cycling occurs
female infertility ( J:207780 )
• despite the presence of vaginal plugs, no newborn pups are obtained

homeostasis/metabolism
abnormal circulating testosterone level ( J:207780 )
• testosterone levels are in the range of wild-type female mice

endocrine/exocrine glands
abnormal ovarian follicle morphology ( J:207780 )
• mice exhibit luteinized unruptured follicles, including oocytes retained in the corpus luteum, unlike wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory