All Phenotypes Ssb<tm2.1Rjma> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ssb^tm2.1Rjma
targeted mutation 2.1, Richard J Maraia
MGI:5569491

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ssb^tm1Rjma/Ssb^tm2.1Rjma Cd79a^tm1(cre)Reth/Cd79a⁺	involves: 129S/SvEv * BALB/c	MGI:5569496
cn2	Ssb^tm1Rjma/Ssb^tm2.1Rjma Tg(Camk2a-cre)T29-1Stl/0	involves: 129S/SvEv * BALB/c * C57BL * C57BL/6	MGI:5569497

Allelic Composition	Ssb^tm1Rjma/Ssb^tm2.1Rjma Cd79a^tm1(cre)Reth/Cd79a⁺
Genetic Background	involves: 129S/SvEv * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^tm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Ssb^tm1Rjma mutation (0 available); any Ssb mutation (32 available)
Ssb^tm2.1Rjma mutation (0 available); any Ssb mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:207687 )

N	• mice exhibit normal splenic CD4+ and CD8+ T cells

arrested B cell differentiation ( J:207687 )

• total block at the pro-B cell to pre-B cell transition

decreased B cell number ( J:207687 )

• severe

small spleen ( J:207687 )

• hyposplenia

decreased spleen weight ( J:207687 )

decreased IgG level ( J:207687 )

• absent

decreased IgM level ( J:207687 )

• absent

hematopoietic system

arrested B cell differentiation ( J:207687 )

• total block at the pro-B cell to pre-B cell transition

decreased B cell number ( J:207687 )

• severe

small spleen ( J:207687 )

• hyposplenia

decreased spleen weight ( J:207687 )

decreased IgG level ( J:207687 )

• absent

decreased IgM level ( J:207687 )

• absent

Allelic Composition	Ssb^tm1Rjma/Ssb^tm2.1Rjma Tg(Camk2a-cre)T29-1Stl/0
Genetic Background	involves: 129S/SvEv * BALB/c * C57BL * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ssb^tm1Rjma mutation (0 available); any Ssb mutation (32 available)
Ssb^tm2.1Rjma mutation (0 available); any Ssb mutation (32 available)
Tg(Camk2a-cre)T29-1Stl mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased brain weight ( J:207687 )

• after 5 weeks

• rapid decline from 13 to 25 weeks, slowed decline afterward

• at 59 to 79 weeks

decreased forebrain size ( J:207687 )

• postnatal loss of forebrain mass at 16 and 32 weeks

forebrain hypoplasia ( J:207687 )

• progressive cell loss

abnormal cerebral cortex morphology ( J:207687 )

• loss of cortical cytoarchitecture at 16 and 32 weeks

thin cerebral cortex ( J:207687 )

• progressive neurodegeneration in the cerebral cortex (starting at 16 weeks) and hippocampus starting

• severely diminished at 65 weeks

abnormal neuron morphology ( J:207687 )

• decrease in neuronal density at 16 and 32 weeks

hippocampus pyramidal cell degeneration ( J:207687 )

• in the CA1 and subiculum

• however, the CA3 and dentate gyrus are relatively spared

neurodegeneration ( J:207687 )

• progressive neurodegeneration in the cerebral cortex and hippocampus

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