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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Myh6-2A)#Know
transgene insertion, Kirk Knowlton
MGI:5569629
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Dmdtm1.1Know/Dmdtm1.1Know
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Tg(Myh6-2A)#Know/0 		involves: BALB/c * C3H * C57BL/6 * FVB/N MGI:5569640
cn2
 		A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Tg(Myh6-2A)#Know/0 		involves: BALB/c * C57BL/6 * FVB/N MGI:5905888


Genotype
MGI:5569640
cn1
Allelic
Composition		 Dmdtm1.1Know/Dmdtm1.1Know
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Tg(Myh6-2A)#Know/0
Genetic
Background		 involves: BALB/c * C3H * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation (5 available); any A1cf mutation (39 available)
Dmdtm1.1Know mutation (0 available); any Dmd mutation (154 available)
Tg(Myh6-2A)#Know mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Inhibition of dilated cardiomyopathy in Dmdtm1.1Know/Dmdtm1.1Know Tg(Myh6-2A)#Know/0 A1cfTg(Myh6-cre/Esr1*)1Jmk/0 mice

cardiovascular system
cardiac fibrosis ( J:207775 )
• less severe fibrosis in tamoxifen-treated mice
increased cardiac muscle contractility ( J:207775 )
• improved cardiac function in tamoxifen-treated mice
abnormal heart echocardiography feature ( J:207775 )
• improved cardiac function in tamoxifen-treated mice
cardiomyopathy ( J:207775 )
• less severe cardiomyopathy in tamoxifen-treated mice

homeostasis/metabolism
decreased susceptibility to injury ( J:207775 )
• tamoxifen-treated mice exhibit less severe cardiomyopathy, cardiac fibrosis and improved cardiac function compared with control mice

muscle
increased cardiac muscle contractility ( J:207775 )
• improved cardiac function in tamoxifen-treated mice
cardiomyopathy ( J:207775 )
• less severe cardiomyopathy in tamoxifen-treated mice




Genotype
MGI:5905888
cn2
Allelic
Composition		 A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Tg(Myh6-2A)#Know/0
Genetic
Background		 involves: BALB/c * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation (5 available); any A1cf mutation (39 available)
Tg(Myh6-2A)#Know mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal myocardial fiber morphology ( J:128060 )
• cardiac cells from tamoxifen-treated mice show severe cytoskeletal changes such as myofibrillar collapse with a haphazard arrangement, a decrease in myofibril number, and an increase in swollen mitochondria
• irregularity in the spacing between cells in the intercalated discs and irregularity of the sarcolemmal membrane in the hearts of tamoxifen-treated mice
abnormal intercalated disk morphology ( J:128060 )
• myocardial fibers of tamoxifen-treated mice show abnormalities of intercalated discs
increased heart atrium size ( J:128060 )
• biatrial enlargement in tamoxifen-treated mice
increased heart ventricle size ( J:128060 )
• severe ventricular enlargement in tamoxifen-treated mice
cardiac interstitial fibrosis ( J:128060 )
• small amount of interstitial fibrosis in tamoxifen-treated mice
dilated cardiomyopathy ( J:128060 )
• heart weight-to-body weight ratio is increased 22 days after tamoxifen administration
decreased heart left ventricle muscle contractility ( J:128060 )
• decrease in the fractional shortening of the left ventricle of tamoxifen-treated mice
abnormal heart echocardiography feature ( J:128060 )
• increase in left ventricular end-diastolic dimension and end-systolic dimension in tamoxifen-treated mice
heart inflammation ( J:128060 )
• tamoxifen-treated mice show only a small increase in inflammation

homeostasis/metabolism
ascites ( J:128060 )
• in tamoxifen-treated mice
pleural effusion ( J:128060 )
• in tamoxifen-treated mice

immune system
heart inflammation ( J:128060 )
• tamoxifen-treated mice show only a small increase in inflammation

muscle
abnormal myocardial fiber morphology ( J:128060 )
• cardiac cells from tamoxifen-treated mice show severe cytoskeletal changes such as myofibrillar collapse with a haphazard arrangement, a decrease in myofibril number, and an increase in swollen mitochondria
• irregularity in the spacing between cells in the intercalated discs and irregularity of the sarcolemmal membrane in the hearts of tamoxifen-treated mice
abnormal intercalated disk morphology ( J:128060 )
• myocardial fibers of tamoxifen-treated mice show abnormalities of intercalated discs
dilated cardiomyopathy ( J:128060 )
• heart weight-to-body weight ratio is increased 22 days after tamoxifen administration
decreased heart left ventricle muscle contractility ( J:128060 )
• decrease in the fractional shortening of the left ventricle of tamoxifen-treated mice
abnormal sarcolemma morphology ( J:128060 )
• the sarcolemmal membrane is disrupted in myocardial fibers of tamoxifen-treated mice
abnormal sarcomere morphology ( J:128060 )
• myocardial fibers from tamoxifen-treated mice show shortened sarcomeres
abnormal Z line morphology ( J:128060 )
• myocardial fibers from tamoxifen-treated mice show fuzzy Z-lines

respiratory system
pleural effusion ( J:128060 )
• in tamoxifen-treated mice

cellular
cardiac interstitial fibrosis ( J:128060 )
• small amount of interstitial fibrosis in tamoxifen-treated mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
dilated cardiomyopathy DOID:12930 OMIM:PS115200
 J:128060




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory