Analysis Tools|
Allele Symbol Allele Name Allele ID |
Ano1tm2Jrr targeted mutation 2, Jason Rock MGI:5569641 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal glomerular filters, podocytes, numbers of reabsorption vesicles in proximal tubular epithelial cells, glomerular filtration rate and urine electrolyte excretion
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 8 to 12 weeks
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• at 8 to 12 weeks
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• at 8 to 12 weeks
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• at P1
• however, this difference faded as animals age
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• macro-albuminuria
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• proximal tubular epithelial (PTE) cells exhibit accumulation of intracellular endosomal vesicles unlike in wild-type cells
• PTE cells are more hyperpolarized and acidic with decreased albumin uptake compared with wild-type cells
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• at 8 to 12 weeks
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• at 8 to 12 weeks
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• at 8 to 12 weeks
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• at 8 to 12 weeks
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• at 8 to 12 weeks
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• at P1
• however, this difference faded as animals age
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• macro-albuminuria
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• calcium-activated chloride ion secretion and effects of niflumic acid are almost completely abolished in the ileum and proximal and distal colon compared with wild-type mice
• however, transport in the jejunum is normal
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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