Phenotypes associated with this allele

• Allele Symbol: Tg(TG-RET/CCDC6)1Cled
• Allele Name: transgene insertion 1, Catherine Ledent
• Allele ID: MGI:5569664
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(TG-RET/CCDC6)1Cled/0	involves: FVB/N	MGI:5897613

Genotype
MGI:5897613

tg1

• Allelic Composition: Tg(TG-RET/CCDC6)1Cled/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased thyroid carcinoma incidence ( J:55883 , J:93679 )

• all mice develop bilateral thyroid tumors by 21 days of age with similarities to human papillary thyroid carcinoma (J:55883)

• administration of exogenous T4 delays thyroid tumor development (J:55883)

• all mice develop bilateral thyroid carcinomas which are invasive into surrounding issues (J:93679)

• tumors contain a mixture of solid, cribiform, and follicular architecture, with a minor degree of papillary infolding and colloid formation is poor or absent (J:93679)

neoplasm

increased thyroid carcinoma incidence ( J:55883 , J:93679 )

• all mice develop bilateral thyroid tumors by 21 days of age with similarities to human papillary thyroid carcinoma (J:55883)

• administration of exogenous T4 delays thyroid tumor development (J:55883)

• all mice develop bilateral thyroid carcinomas which are invasive into surrounding issues (J:93679)

• tumors contain a mixture of solid, cribiform, and follicular architecture, with a minor degree of papillary infolding and colloid formation is poor or absent (J:93679)