Phenotypes associated with this allele

• Allele Symbol: Tg(TG-RET/NCOA4)3209Rstn
• Allele Name: transgene insertion 3209, Jay Rothstein
• Allele ID: MGI:5569734
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(TG-RET/NCOA4)3209Rstn/0	involves: C57BL/6	MGI:5897625

Genotype
MGI:5897625

tg1

• Allelic Composition: Tg(TG-RET/NCOA4)3209Rstn/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal thyroid gland morphology ( J:51366 )

• architecture of thyroids is severely altered and thyroglobulin production is active

abnormal thyroid follicular cell morphology ( J:51366 )

• glandular hypertrophy is due to follicular cell hyperplasia

enlarged thyroid gland ( J:51366 )

• hypertrophy of the thyroid gland is seen starting at 2 months of age, with each lobe on average 3-4 times normal size

increased thyroid carcinoma incidence ( J:51366 )

• thyroids from mice younger than 3 months of age show signs of cellular transformation characterized as follicular cell hyperplasia and dysplastic follicles

• mice 3 months of age or older develop solid subtype of papillary thyroid carcinoma

• thyroid carcinomas present as large regions of tissue devoid of follicles or papillae

neoplasm

increased thyroid carcinoma incidence ( J:51366 )

• thyroids from mice younger than 3 months of age show signs of cellular transformation characterized as follicular cell hyperplasia and dysplastic follicles

• mice 3 months of age or older develop solid subtype of papillary thyroid carcinoma

• thyroid carcinomas present as large regions of tissue devoid of follicles or papillae

increased metastatic potential ( J:51366 )

• 33% of mice show metastasis in lymph nodes, with the metastatic tumor showing papillary features of thyroid carcinoma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
papillary thyroid carcinoma		DOID:3969	OMIM:188550	J:51366