Phenotypes associated with this allele

• Allele Symbol: Tg(TG-TPR/NTRK1)#Rstn
• Allele Name: transgene insertion, Jay Rothstein
• Allele ID: MGI:5569754
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf Tg(TG-TPR/NTRK1)#Rstn/0	involves: 129S4/SvJaeSor * C3H * C57BL/6 * C57BL/6J	MGI:5581426
cx2	Cdkn1b^tm1Mlf/Cdkn1b^+ Tg(TG-TPR/NTRK1)#Rstn/0	involves: 129S4/SvJaeSor * C3H * C57BL/6 * C57BL/6J	MGI:5581427
tg3	Tg(TG-TPR/NTRK1)#Rstn/0	involves: 129S4/SvJaeSor * C3H * C57BL/6 * C57BL/6J	MGI:5581425

Genotype
MGI:5581426

cx1

• Allelic Composition: Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf; Tg(TG-TPR/NTRK1)#Rstn/0
• Genetic Background: involves: 129S4/SvJaeSor * C3H * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased thyroid carcinoma incidence ( J:210015 )

• mice show a higher incidence of papillary thyroid carcinoma with a shorter latency period and increased proliferation index compared to single transgenic Tg(TG-TPR/NTRK1)#Rstn mice

• total number of papillary thyroid carcinomas is higher than in mice heterozygous for Cdkn1b^tm1Mlf and transgenic for Tg(TG-TPR/NTRK1)#Rstn

• tumor metastases to local cervical lymph nodes, peripheral lymph nodes or lungs are not seen

endocrine/exocrine glands

increased thyroid carcinoma incidence ( J:210015 )

• mice show a higher incidence of papillary thyroid carcinoma with a shorter latency period and increased proliferation index compared to single transgenic Tg(TG-TPR/NTRK1)#Rstn mice

• total number of papillary thyroid carcinomas is higher than in mice heterozygous for Cdkn1b^tm1Mlf and transgenic for Tg(TG-TPR/NTRK1)#Rstn

• tumor metastases to local cervical lymph nodes, peripheral lymph nodes or lungs are not seen

Genotype
MGI:5581427

cx2

• Allelic Composition: Cdkn1b^tm1Mlf/Cdkn1b⁺; Tg(TG-TPR/NTRK1)#Rstn/0
• Genetic Background: involves: 129S4/SvJaeSor * C3H * C57BL/6 * C57BL/6J

neoplasm

increased thyroid carcinoma incidence ( J:210015 )

• total number of papillary thyroid carcinomas that form is higher than in single Tg(TG-TPR/NTRK1)#Rstn transgenic mice

• however, a delay in onset of papillary thyroid carcinoma is seen compared to mice homozygous for Cdkn1b^tm1Mlf and transgenic for Tg(TG-TPR/NTRK1)#Rstn mice

endocrine/exocrine glands

increased thyroid carcinoma incidence ( J:210015 )

• total number of papillary thyroid carcinomas that form is higher than in single Tg(TG-TPR/NTRK1)#Rstn transgenic mice

• however, a delay in onset of papillary thyroid carcinoma is seen compared to mice homozygous for Cdkn1b^tm1Mlf and transgenic for Tg(TG-TPR/NTRK1)#Rstn mice

Genotype
MGI:5581425

tg3

• Allelic Composition: Tg(TG-TPR/NTRK1)#Rstn/0
• Genetic Background: involves: 129S4/SvJaeSor * C3H * C57BL/6 * C57BL/6J

neoplasm

increased thyroid carcinoma incidence ( J:210015 )

• mice develop papillary thyroid carcinoma

endocrine/exocrine glands

increased thyroid carcinoma incidence ( J:210015 )

• mice develop papillary thyroid carcinoma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
thyroid cancer		DOID:1781		J:210015