All Phenotypes Islr2<tm2.1Ddg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Islr2^tm2.1Ddg
targeted mutation 2.1, David D Ginty
MGI:5569767

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Islr2^tm1.1Ddg/Islr2^tm2.1Ddg Emx1^tm1(cre)Krj/Emx1⁺	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * SJL	MGI:5569795
cn2	Islr2^tm1.1Ddg/Islr2^tm2.1Ddg Tg(mI56i-cre,EGFP)1Kc/0	involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL	MGI:5569796

Allelic Composition	Islr2^tm1.1Ddg/Islr2^tm2.1Ddg Emx1^tm1(cre)Krj/Emx1⁺
Genetic Background	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1^tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)
Islr2^tm1.1Ddg mutation (1 available); any Islr2 mutation (24 available)
Islr2^tm2.1Ddg mutation (1 available); any Islr2 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:210221 )

• some mice die during the fourth postnatal week

nervous system

abnormal brain morphology ( J:210221 )

• hypoplastic thalamocortical projections

• few, if any, corticofugal and thalamocortical axons cross the pallial-subpallial boundary

• however, thalamocortical projections extension through the diencephalic-telencephalic boundary is normal

abnormal telencephalon development ( J:210221 )

• at P7, pallium and subpallium are almost completely disconnected

abnormal brain internal capsule morphology ( J:210221 )

• the main trunk is devoid of corticofugal axons

Allelic Composition	Islr2^tm1.1Ddg/Islr2^tm2.1Ddg Tg(mI56i-cre,EGFP)1Kc/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Islr2^tm1.1Ddg mutation (1 available); any Islr2 mutation (24 available)
Islr2^tm2.1Ddg mutation (1 available); any Islr2 mutation (24 available)
Tg(mI56i-cre,EGFP)1Kc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:210221 )

• some mice die during the fourth postnatal week

nervous system

abnormal brain morphology ( J:210221 )

• thalamic projections are misrouted into the ventral midbrain and tangled within the hypothalamus and near complete absence of corticofugal and thalamocortical axons that cross the pallial-subpallial boundary unlike in wild-type mice

abnormal telencephalon development ( J:210221 )

• at P7, pallium and subpallium are nearly completely disconnected

abnormal brain internal capsule morphology ( J:210221 )

• disorganized with partially formed rostral part of the tract

decreased corticospinal tract size ( J:210221 )

• absent at P7

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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