Phenotypes associated with this allele

• Allele Symbol: Mylk3^tm1.1Hkas
• Allele Name: targeted mutation 1.1, Hideko Kasahara
• Allele ID: MGI:5569908
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mylk3^tm1.1Hkas/Mylk3^tm1.1Hkas	involves: 129 * C57BL/6 * FVB/N	MGI:5569931

Genotype
MGI:5569931

hm1

• Allelic Composition: Mylk3^tm1.1Hkas/Mylk3^tm1.1Hkas
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:210147 )

• following transverse aortic constriction or swimming exercise

cardiovascular system

abnormal heart morphology ( J:210147 )

• decreased cardiac torsion

increased myocardial fiber size ( J:210147 )

• isolated from ventricle

thin interventricular septum ( J:210147 )

• following transverse aortic constriction

enlarged heart ( J:210147 )

• moderately along the long axis

increased heart weight ( J:210147 )

• at 3 and 6 months

• following transverse aortic constriction

abnormal heart left ventricle morphology ( J:210147 )

• increased left ventricle volume at end systole and end diastole prior to and following transverse aortic constriction

decreased cardiac muscle contractility ( J:210147 )

• prior to and following transverse aortic constriction

• exercise does not improve cardiac contraction

abnormal heart left ventricle pressure ( J:210147 )

• following transverse aortic constriction, mice fail to exhibit an increase in left ventricle end-systolic pressure but an increase in end-diastolic pressure unlike wild-type mice

abnormal heart electrocardiography waveform feature ( J:210147 )

• prolonged ventricular depolarization

prolonged QRS complex duration ( J:210147 )

• small prolongation

abnormal myocardial fiber physiology ( J:210147 )

• reduced contractility and speed of relaxation

• however, amplitude of intracellular calcium transient is normal

increased response of heart to induced stress ( J:210147 )

• after transverse aortic constriction, mice exhibit profound heart failure, increased heart size, decreased survival rate, increased heart weight, increase in end-diastolic pressure and decreased ventricle contraction and relaxation compared with wild-type mice

congestive heart failure ( J:210147 )

• following transverse aortic constriction

homeostasis/metabolism

increased response of heart to induced stress ( J:210147 )

• after transverse aortic constriction, mice exhibit profound heart failure, increased heart size, decreased survival rate, increased heart weight, increase in end-diastolic pressure and decreased ventricle contraction and relaxation compared with wild-type mice

abnormal response to exercise ( J:210147 )

• exercise does not improve cardiac contraction

• however, exercised mice exhibit an increase in heart weight as in wild-type mice

muscle

increased myocardial fiber size ( J:210147 )

• isolated from ventricle

decreased cardiac muscle contractility ( J:210147 )

• prior to and following transverse aortic constriction

• exercise does not improve cardiac contraction

growth/size/body

enlarged heart ( J:210147 )

• moderately along the long axis

increased heart weight ( J:210147 )

• at 3 and 6 months

• following transverse aortic constriction