All Phenotypes Ptges<tm1.1Gaf> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ptges^tm1.1Gaf
targeted mutation 1.1, Garret FitzGerald
MGI:5570356

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ptges^tm1.1Gaf/Ptges^tm1.1Gaf Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129 * C57BL/6	MGI:5570434
cn2	Ptges^tm1.1Gaf/Ptges^tm1.1Gaf Tg(Tagln-cre)1Her/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:5570433
cn3	Ptges^tm1.1Gaf/Ptges^tm1.1Gaf Tg(Tek-cre)1Ywa/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:5570546

Allelic Composition	Ptges^tm1.1Gaf/Ptges^tm1.1Gaf Lyz2^tm1(cre)Ifo/Lyz2⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2^tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
Ptges^tm1.1Gaf mutation (0 available); any Ptges mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal vascular wound healing ( J:210141 )

• following wire injury, mice exhibit decreased intima to media ratio and stenosis percent with increased leukocyte recruitment compared with control mice

decreased prostaglandin level ( J:210141 )

• decreased LPS-stimulated prostaglandin E2

• however, LPS-stimulated prostaglandin D2 levels are normal

increased prostaglandin level ( J:210141 )

• increased LPS-stimulated prostaglandin I2 levels

immune system

increased leukocyte cell number ( J:210141 )

• increased leukocyte recruitment following wire injury

abnormal leukocyte physiology ( J:210141 )

• increased leukocyte recruitment following wire injury

cardiovascular system

abnormal vascular wound healing ( J:210141 )

• following wire injury, mice exhibit decreased intima to media ratio and stenosis percent with increased leukocyte recruitment compared with control mice

hematopoietic system

increased leukocyte cell number ( J:210141 )

• increased leukocyte recruitment following wire injury

abnormal leukocyte physiology ( J:210141 )

• increased leukocyte recruitment following wire injury

Allelic Composition	Ptges^tm1.1Gaf/Ptges^tm1.1Gaf Tg(Tagln-cre)1Her/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptges^tm1.1Gaf mutation (0 available); any Ptges mutation (48 available)
Tg(Tagln-cre)1Her mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal vascular wound healing ( J:210141 )

• following wire injury, mice exhibit accelerated intimal hyperplasia with increased intima to media ratio and stenosis percent compared with control mice

decreased prostaglandin level ( J:210141 )

• decreased IL1beta-stimulated prostaglandin E2

increased prostaglandin level ( J:210141 )

• increased IL1beta-stimulated prostaglandin D2 and I2 levels

cardiovascular system

cardiovascular system phenotype ( J:210141 )

N	• whether fed standard chow or a high salt diet, mice exhibit normal modulation of blood pressure and thrombogenesis

abnormal vascular wound healing ( J:210141 )

• following wire injury, mice exhibit accelerated intimal hyperplasia with increased intima to media ratio and stenosis percent compared with control mice

Allelic Composition	Ptges^tm1.1Gaf/Ptges^tm1.1Gaf Tg(Tek-cre)1Ywa/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptges^tm1.1Gaf mutation (0 available); any Ptges mutation (48 available)
Tg(Tek-cre)1Ywa mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal vascular wound healing ( J:210141 )

• following wire injury, mice exhibit accelerated intimal hyperplasia with increased intima to media ratio and stenosis percent compared with control mice

decreased prostaglandin level ( J:210141 )

• decreased IL1beta-stimulated prostaglandin E2

increased prostaglandin level ( J:210141 )

• increased IL1beta-stimulated prostaglandin D2 and I2 levels

cardiovascular system

cardiovascular system phenotype ( J:210141 )

N	• whether fed standard chow or a high salt diet, mice exhibit normal modulation of blood pressure and thrombogenesis

abnormal vascular wound healing ( J:210141 )

• following wire injury, mice exhibit accelerated intimal hyperplasia with increased intima to media ratio and stenosis percent compared with control mice

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