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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl11btm2.1Jpk
targeted mutation 2.1, Japan Kominami
MGI:5571289
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Bcl11btm2.1Jpk/Bcl11b+
Tg(Lck-cre)1Jtak/0 		involves: C57BL/6 MGI:5571296
cn2
 		Bcl11btm2.1Jpk/Bcl11b+
Tg(Cd4-cre)1Cwi/0 		involves: C57BL/6 * C57BL/6J * DBA/2 MGI:5571295


Genotype
MGI:5571296
cn1
Allelic
Composition		 Bcl11btm2.1Jpk/Bcl11b+
Tg(Lck-cre)1Jtak/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11btm2.1Jpk mutation (2 available); any Bcl11b mutation (46 available)
Tg(Lck-cre)1Jtak mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell number ( J:210122 )
• increased percentage of immature single positive cells in irradiated mice
decreased thymocyte number ( J:210122 )
• in irradiated mice
increased double-negative T cell number ( J:210122 )
• increased percentage in irradiated mice
decreased double-positive T cell number ( J:210122 )
• decreased percent in irradiated mice
decreased CD4-positive, alpha-beta T cell number ( J:210122 )
• decreased percent in irradiated mice
decreased CD8-positive, alpha-beta T cell number ( J:210122 )
• decreased percent in irradiated mice

neoplasm
increased lymphoma incidence ( J:210122 )
• thymic lymphomas in 4 of 5 irradiated mice

cellular
abnormal cell cycle ( J:210122 )
• attenuated radiation-induced cell cycle arrest at the S phase in immature single positive cells of irradiated mice

endocrine/exocrine glands
decreased thymocyte number ( J:210122 )
• in irradiated mice

hematopoietic system
abnormal T cell number ( J:210122 )
• increased percentage of immature single positive cells in irradiated mice
decreased thymocyte number ( J:210122 )
• in irradiated mice
increased double-negative T cell number ( J:210122 )
• increased percentage in irradiated mice
decreased double-positive T cell number ( J:210122 )
• decreased percent in irradiated mice
decreased CD4-positive, alpha-beta T cell number ( J:210122 )
• decreased percent in irradiated mice
decreased CD8-positive, alpha-beta T cell number ( J:210122 )
• decreased percent in irradiated mice




Genotype
MGI:5571295
cn2
Allelic
Composition		 Bcl11btm2.1Jpk/Bcl11b+
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6 * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11btm2.1Jpk mutation (2 available); any Bcl11b mutation (46 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:210122 )
N
• gamma-irradiated thymus do not exhibit clonal growth of thymocytes or changes in thymocyte numbers or differentiation




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory