Phenotypes associated with this allele

• Allele Symbol: Septin5^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5571344
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Septin5^tm1b(EUCOMM)Hmgu/Septin5^tm1b(EUCOMM)Hmgu	C57BL/6N-Septin5^tm1b(EUCOMM)Hmgu/Rbrc	MGI:5767797
ht2	Septin5^tm1b(EUCOMM)Hmgu/Septin5^+	C57BL/6N-Septin5^tm1b(EUCOMM)Hmgu/Rbrc	MGI:5813028

Genotype
MGI:5767797

hm1

• Allelic Composition: Septin5^{tm1b(EUCOMM)Hmgu}/Septin5^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Septin5^{tm1b(EUCOMM)Hmgu}/Rbrc
• Cell Lines: HEPD0724_4_B10

Data Sources

IMPC Data for Septin5

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - RBRC

Genotype
MGI:5813028

ht2

• Allelic Composition: Septin5^{tm1b(EUCOMM)Hmgu}/Septin5⁺
• Genetic Background: C57BL/6N-Septin5^{tm1b(EUCOMM)Hmgu}/Rbrc
• Cell Lines: HEPD0724_4_B10

Data Sources

IMPC Data for Septin5

growth/size/body

decreased body length ( J:211773 )

♀

IMPC - RBRC

hematopoietic system

thrombocytopenia ( J:211773 )

IMPC - RBRC

small spleen ( J:211773 )

♀

IMPC - RBRC

homeostasis/metabolism

improved glucose tolerance ( J:211773 )

IMPC - RBRC

immune system

small spleen ( J:211773 )

♀

IMPC - RBRC

limbs/digits/tail

short tibia ( J:211773 )

IMPC - RBRC

skeleton

short tibia ( J:211773 )

IMPC - RBRC

abnormal bone structure ( J:211773 )

♀

IMPC - RBRC

decreased bone mineral content ( J:211773 )

♀

IMPC - RBRC

decreased bone mineral density ( J:211773 )

♀

IMPC - RBRC