All Phenotypes Tg(Igh-ROR1)1Kip MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Igh-ROR1)1Kip/0 Tg(Igh-V186.2-TCL1A)3Cro/0	B6.Cg-Tg(Igh-ROR1)1Kip Tg(Igh-V186.2-TCL1A)3Cro	MGI:5571374
tg2	Tg(Igh-ROR1)1Kip/0	C57BL/6-Tg(Igh-ROR1)1Kip	MGI:5571369

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased chronic lymphocytic leukemia incidence ( J:206368 )

• develop leukemia at a younger median age than mice with either transgene alone

• expansion of CD5+B220^low B cells is accelerated and mice show earlier development of leukemia compared to single Tg(Igh-ROR1)1Kip mice

mortality/aging

premature death ( J:206368 )

• median survival is 50.6 weeks

hematopoietic system

enlarged spleen ( J:206368 )

increased lymphocyte cell number ( J:206368 )

• develop CD5+B220^low B-cell lymphocytosis at a younger median age than mice with either transgene alone

increased mature B cell number ( J:206368 )

• double mutants show an increase in percentage of CD5+B220^low B cells among blood lymphocytes compared to single Tg(Igh-V186.2-TCL1A)3Cro mice

immune system

enlarged spleen ( J:206368 )

increased lymphocyte cell number ( J:206368 )

• develop CD5+B220^low B-cell lymphocytosis at a younger median age than mice with either transgene alone

increased mature B cell number ( J:206368 )

• double mutants show an increase in percentage of CD5+B220^low B cells among blood lymphocytes compared to single Tg(Igh-V186.2-TCL1A)3Cro mice

growth/size/body

enlarged spleen ( J:206368 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic lymphocytic leukemia		DOID:1040	OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559	J:206368

Allelic Composition	Tg(Igh-ROR1)1Kip/0
Genetic Background	C57BL/6-Tg(Igh-ROR1)1Kip

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♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

enlarged spleen ( J:206368 )

• develops in 5% of mice

increased lymphocyte cell number ( J:206368 )

• increase in numbers of splenic lymphocytes

• 5% of mice develop lymphocytosis and splenomegaly due to accumulations of clonal ROR1^bright CD5+B220^low B cells

increased mature B cell number ( J:206368 )

• develop mature B cells in the blood, spleen, marrow and peritoneal cavity

immune system

enlarged spleen ( J:206368 )

• develops in 5% of mice

increased lymphocyte cell number ( J:206368 )

• increase in numbers of splenic lymphocytes

• 5% of mice develop lymphocytosis and splenomegaly due to accumulations of clonal ROR1^bright CD5+B220^low B cells

increased mature B cell number ( J:206368 )

• develop mature B cells in the blood, spleen, marrow and peritoneal cavity

neoplasm

increased chronic lymphocytic leukemia incidence ( J:206368 )

• 5% of mice develop clonal expansions of ROR1^bright CD5+B220^low B cells resembling human chronic lymphocytic leukemia

growth/size/body

enlarged spleen ( J:206368 )

• develops in 5% of mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic lymphocytic leukemia		DOID:1040	OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559	J:206368

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