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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kittm2.1(cre/Esr1*)Jmol
targeted mutation 2.1, Jeffery D Molkentin
MGI:5571475
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Kittm1.1(cre)Jmol/Kittm2.1(cre/Esr1*)Jmol involves: 129/Sv * 129S4/SvJaeSor * C57BL/6J MGI:5571489
cn2
 		Kittm1.1(cre)Jmol/Kittm2.1(cre/Esr1*)Jmol
Gt(ROSA)26Sortm1(CAG-lacZ,-EGFP)Glh/Gt(ROSA)26Sor+ 		involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB MGI:5571491
cn3
 		Kittm1.1(cre)Jmol/Kittm2.1(cre/Esr1*)Jmol
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+ 		involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J MGI:5571490


Genotype
MGI:5571489
ht1
Allelic
Composition		 Kittm1.1(cre)Jmol/Kittm2.1(cre/Esr1*)Jmol
Genetic
Background		 involves: 129/Sv * 129S4/SvJaeSor * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kittm1.1(cre)Jmol mutation (1 available); any Kit mutation (182 available)
Kittm2.1(cre/Esr1*)Jmol mutation (1 available); any Kit mutation (182 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:210584 )
• animals die at birth, but viable fetuses are observed at E16.5 and E18.5




Genotype
MGI:5571491
cn2
Allelic
Composition		 Kittm1.1(cre)Jmol/Kittm2.1(cre/Esr1*)Jmol
Gt(ROSA)26Sortm1(CAG-lacZ,-EGFP)Glh/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-lacZ,-EGFP)Glh mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Kittm1.1(cre)Jmol mutation (1 available); any Kit mutation (182 available)
Kittm2.1(cre/Esr1*)Jmol mutation (1 available); any Kit mutation (182 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:210584 )
• animals die at birth, but viable fetuses are observed at E16.5 and E18.5; no Kit protein is detected by Western blot

cardiovascular system
abnormal heart development ( J:210584 )
• at E18.5, hearts have lower total numbers of EGFP-positive cells compared to controls and no EGFP-positive cardiomyocytes




Genotype
MGI:5571490
cn3
Allelic
Composition		 Kittm1.1(cre)Jmol/Kittm2.1(cre/Esr1*)Jmol
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo mutation (10 available); any Gt(ROSA)26Sor mutation (993 available)
Kittm1.1(cre)Jmol mutation (1 available); any Kit mutation (182 available)
Kittm2.1(cre/Esr1*)Jmol mutation (1 available); any Kit mutation (182 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:210584 )
• animals die at birth, but viable fetuses are observed at E16.5 and E18.5; no Kit protein is detected by Western blot

cardiovascular system
abnormal heart development ( J:210584 )
• at E16.5, hearts have lower total numbers of EGFP-positive cells compared to controls, and no EGFP-positive cardiomyocytes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory