All Phenotypes Ahr<tm1.2Arte> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ahr^tm1.2Arte
targeted mutation 1.2, TaconicArtemis
MGI:5571477

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ahr^tm1.2Arte/Ahr^tm1.2Arte	involves: C57BL/6NTac	MGI:5571486

Allelic Composition	Ahr^tm1.2Arte/Ahr^tm1.2Arte
Genetic Background	involves: C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ahr^tm1.2Arte mutation (2 available); any Ahr mutation (112 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

teratozoospermia ( J:210360 )

• flattening of the base of the head, loss of the typical hook-shaped head, changes in the flagellum such as a folded or coiled tail, and the presence of a cytoplasmic droplet

• however, mice exhibit normal sperm count, average motility and progressive motility

coiled sperm flagellum ( J:210360 )

• folded or coiled

abnormal sperm head morphology ( J:210360 )

• flattening of the base of the head and loss of the typical hook-shaped head

multinucleated giant male germ cells ( J:210360 )

abnormal male germ cell apoptosis ( J:210360 )

• in the seminiferous tubules

abnormal seminiferous tubule epithelium morphology ( J:210360 )

• hypocellularity with widened intercellular spaces, multinucleated giant cells and vacuoles

seminiferous tubule degeneration ( J:210360 )

• with increased apoptotic cells

decreased testis weight ( J:210360 )

abnormal spermiation ( J:210360 )

• failure of spermatids to disengage indicated by excess numbers of retained spermatids in the basal compartment of the seminiferous epithelium

abnormal cauda epididymis morphology ( J:210360 )

• decreased weight

decreased epididymis weight ( J:210360 )

decreased fertilization frequency ( J:210360 )

• as determined by in vitro fertilization with increased progression of two-cell embryos to blastocyst-stage embryos

cellular

teratozoospermia ( J:210360 )

• flattening of the base of the head, loss of the typical hook-shaped head, changes in the flagellum such as a folded or coiled tail, and the presence of a cytoplasmic droplet

• however, mice exhibit normal sperm count, average motility and progressive motility

coiled sperm flagellum ( J:210360 )

• folded or coiled

abnormal sperm head morphology ( J:210360 )

• flattening of the base of the head and loss of the typical hook-shaped head

multinucleated giant male germ cells ( J:210360 )

abnormal male germ cell apoptosis ( J:210360 )

• in the seminiferous tubules

endocrine/exocrine glands

abnormal seminiferous tubule epithelium morphology ( J:210360 )

• hypocellularity with widened intercellular spaces, multinucleated giant cells and vacuoles

seminiferous tubule degeneration ( J:210360 )

• with increased apoptotic cells

decreased testis weight ( J:210360 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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