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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lmnatm10Lgf
targeted mutation 10, Loren G Fong
MGI:5571497
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lmnatm10Lgf/Lmnatm10Lgf involves: 129P2/OlaHsd * C57BL/6 MGI:5571570
cx2
 		Lmnatm10Lgf/Lmnatm10Lgf
Zmpste24tm1Sgy/Zmpste24tm1Sgy 		involves: 129P2/OlaHsd * 129S4/SvJae MGI:5754490


Genotype
MGI:5571570
hm1
Allelic
Composition		 Lmnatm10Lgf/Lmnatm10Lgf
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm10Lgf mutation (0 available); any Lmna mutation (84 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:207144 )
N
• mice exhibit normal viability

nervous system
nervous system phenotype ( J:207144 )
N
• mice exhibit normal brain size and morphology

behavior/neurological
behavior/neurological phenotype ( J:207144 )
N
• mice exhibit normal behavior and performance on a rotarod




Genotype
MGI:5754490
cx2
Allelic
Composition		 Lmnatm10Lgf/Lmnatm10Lgf
Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm10Lgf mutation (0 available); any Lmna mutation (84 available)
Zmpste24tm1Sgy mutation (2 available); any Zmpste24 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal esophageal squamous epithelium morphology ( J:220988 )
• esophagus shows a cornified squamous epithelium
dilated esophagus ( J:220988 )
• mice develop dilated, yellow esophagus
abnormal colon morphology ( J:220988 )
• dilated proximal colon
esophageal achalasia ( J:220988 )
• thinning and fibrosis of the muscularis externa, pathology similar to achalasia

muscle
esophageal achalasia ( J:220988 )
• thinning and fibrosis of the muscularis externa, pathology similar to achalasia

nervous system
nervous system phenotype ( J:220988 )
N
• mice show no pathology in the central nervous system

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
achalasia DOID:9164 OMIM:200400
 J:220988




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory