About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rapgef4tm1.2Chen
targeted mutation 1.2, Ju Chen
MGI:5571845
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rapgef4tm1.2Chen/Rapgef4tm1.2Chen involves: 129 * Black Swiss * C57BL/6 * SJL MGI:5571873
cx2
 		Rapgef3tm1.2Chen/Rapgef3tm1.2Chen
Rapgef4tm1.2Chen/Rapgef4tm1.2Chen 		involves: 129 * Black Swiss * C57BL/6 * SJL MGI:5571874


Genotype
MGI:5571873
hm1
Allelic
Composition		 Rapgef4tm1.2Chen/Rapgef4tm1.2Chen
Genetic
Background		 involves: 129 * Black Swiss * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rapgef4tm1.2Chen mutation (1 available); any Rapgef4 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:210426 )
N
• mice exhibit normal baseline cardiac function and response to transverse aortic constriction
ventricular tachycardia ( J:210426 )
• reduced tendency to ventricular tachycardia after a burst pacing protocol compared with wild-type mice
• however, mice exhibit normal heart rate, ECG parameters and refractory periods at baseline or in response to isoproterenol

muscle
abnormal sarcoplasmic reticulum morphology ( J:210426 )
• 8-CPT-induced increase in calcium spark frequency (a measure of sarcoplasmic leak) is abolished prior to or after isoproterenol treatment




Genotype
MGI:5571874
cx2
Allelic
Composition		 Rapgef3tm1.2Chen/Rapgef3tm1.2Chen
Rapgef4tm1.2Chen/Rapgef4tm1.2Chen
Genetic
Background		 involves: 129 * Black Swiss * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rapgef3tm1.2Chen mutation (0 available); any Rapgef3 mutation (47 available)
Rapgef4tm1.2Chen mutation (1 available); any Rapgef4 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:210426 )
N
• mice exhibit normal baseline cardiac function and response to transverse aortic constriction

muscle
abnormal sarcoplasmic reticulum morphology ( J:210426 )
• 8-CPT-induced increase in calcium spark frequency (a measure of sarcoplasmic leak) is abolished




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory