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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rapgef3tm1.2Chen
targeted mutation 1.2, Ju Chen
MGI:5571846
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rapgef3tm1.2Chen/Rapgef3tm1.2Chen involves: 129 * Black Swiss * C57BL/6 * SJL MGI:5571871
cx2
 		Rapgef3tm1.2Chen/Rapgef3tm1.2Chen
Rapgef4tm1.2Chen/Rapgef4tm1.2Chen 		involves: 129 * Black Swiss * C57BL/6 * SJL MGI:5571874


Genotype
MGI:5571871
hm1
Allelic
Composition		 Rapgef3tm1.2Chen/Rapgef3tm1.2Chen
Genetic
Background		 involves: 129 * Black Swiss * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rapgef3tm1.2Chen mutation (0 available); any Rapgef3 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:210426 )
N
• mice exhibit normal baseline cardiac function and response to transverse aortic constriction




Genotype
MGI:5571874
cx2
Allelic
Composition		 Rapgef3tm1.2Chen/Rapgef3tm1.2Chen
Rapgef4tm1.2Chen/Rapgef4tm1.2Chen
Genetic
Background		 involves: 129 * Black Swiss * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rapgef3tm1.2Chen mutation (0 available); any Rapgef3 mutation (47 available)
Rapgef4tm1.2Chen mutation (1 available); any Rapgef4 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:210426 )
N
• mice exhibit normal baseline cardiac function and response to transverse aortic constriction

muscle
abnormal sarcoplasmic reticulum morphology ( J:210426 )
• 8-CPT-induced increase in calcium spark frequency (a measure of sarcoplasmic leak) is abolished




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory