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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Plgtm1.1Fjc
targeted mutation 1.1, Francis J Castellino
MGI:5571896
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Plgtm1.1Fjc/Plgtm1.1Fjc involves: C57BL/6 * C57BL/6JJcl MGI:5571918


Genotype
MGI:5571918
hm1
Allelic
Composition		 Plgtm1.1Fjc/Plgtm1.1Fjc
Genetic
Background		 involves: C57BL/6 * C57BL/6JJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plgtm1.1Fjc mutation (0 available); any Plg mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal rectum morphology ( J:210802 )
• focal ulceration, inflammation, and fibrin deposition at the ano-rectal junction

immune system
increased circulating fibrinogen level ( J:210802 )
• resting plasma fibrinogen levels at 4 to 36 weeks, increasing with age
enlarged lymph nodes ( J:210802 )
• proximal to the pancreas

liver/biliary system
liver fibrosis ( J:210802 )
• fibrin deposits and micrcalcifications

growth/size/body
postnatal growth retardation ( J:210802 )

homeostasis/metabolism
increased circulating fibrinogen level ( J:210802 )
• resting plasma fibrinogen levels at 4 to 36 weeks, increasing with age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory