normal phenotype
• mice do not show any developmental or growth defects with normal Cd4 to CD8 ratio
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Allele Symbol Allele Name Allele ID |
Patz1tm1.2Welm targeted mutation 1.2, Wilfried Ellmeier MGI:5572819 |
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Summary |
3 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice do not show any developmental or growth defects with normal Cd4 to CD8 ratio
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice subjected to systemic anaphylaxis exhibit normal histamine release response of mast cells in vivo
• mice exhibit normal cutaneous anaphylaxis response
• bone marrow-derived mast cells exhibit normal early and late effector functions upon Fcer1-mediated activation
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• bone marrow cultures yield less bone marrow-derived mast cells compared with wild-type cultures
• however, in vivo numbers of mast cells in the ear skin are normal
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• in bone marrow-derived mast cells activated with TNP
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• bone marrow cultures yield less bone marrow-derived mast cells compared with wild-type cultures
• however, in vivo numbers of mast cells in the ear skin are normal
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• bone marrow cultures yield less bone marrow-derived mast cells compared with wild-type cultures
• however, in vivo numbers of mast cells in the ear skin are normal
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice exhibit normal numbers of peritoneal mast cells
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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