All Phenotypes Patz1<tm1.2Welm> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Patz1^tm1.2Welm
targeted mutation 1.2, Wilfried Ellmeier
MGI:5572819

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Patz1^tm1.2Welm/Patz1^tm1.2Welm	involves: 129P2/OlaHsd	MGI:5572829
cn2	Patz1^tm1.2Welm/Patz1^tm1.2Welm Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺	B6.Cg-Patz1^tm1.2Welm Commd10^{Tg(Vav1-icre)A2Kio}	MGI:5572830
cn3	Patz1^tm1.2Welm/Patz1^tm1.2Welm Tg(Cma1-cre)#Roer/0	involves: 129P2/OlaHsd * C57BL/6	MGI:5572831

Allelic Composition	Patz1^tm1.2Welm/Patz1^tm1.2Welm
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Patz1^tm1.2Welm mutation (0 available); any Patz1 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:209168 )

• mice do not show any developmental or growth defects with normal Cd4 to CD8 ratio

Allelic Composition	Patz1^tm1.2Welm/Patz1^tm1.2Welm Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
Genetic Background	B6.Cg-Patz1^tm1.2Welm Commd10^{Tg(Vav1-icre)A2Kio}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10^{Tg(Vav1-icre)A2Kio} mutation (3 available); any Commd10 mutation (24 available)
Patz1^tm1.2Welm mutation (0 available); any Patz1 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:209168 )

N	• mice subjected to systemic anaphylaxis exhibit normal histamine release response of mast cells in vivo • mice exhibit normal cutaneous anaphylaxis response • bone marrow-derived mast cells exhibit normal early and late effector functions upon Fcer1-mediated activation

abnormal mast cell differentiation ( J:209168 )

• bone marrow cultures yield less bone marrow-derived mast cells compared with wild-type cultures

• however, in vivo numbers of mast cells in the ear skin are normal

decreased interleukin-6 secretion ( J:209168 )

• in bone marrow-derived mast cells activated with TNP

cellular

abnormal mast cell differentiation ( J:209168 )

• bone marrow cultures yield less bone marrow-derived mast cells compared with wild-type cultures

• however, in vivo numbers of mast cells in the ear skin are normal

hematopoietic system

abnormal mast cell differentiation ( J:209168 )

• bone marrow cultures yield less bone marrow-derived mast cells compared with wild-type cultures

• however, in vivo numbers of mast cells in the ear skin are normal

Allelic Composition	Patz1^tm1.2Welm/Patz1^tm1.2Welm Tg(Cma1-cre)#Roer/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Patz1^tm1.2Welm mutation (0 available); any Patz1 mutation (55 available)
Tg(Cma1-cre)#Roer mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:209168 )

N	• mice exhibit normal numbers of peritoneal mast cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24