Phenotypes associated with this allele

• Allele Symbol: Rgs3^tm1Ndul
• Allele Name: targeted mutation 1, Nickolai O Dulin
• Allele ID: MGI:5572935
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rgs3^tm1Ndul/Rgs3^tm1Ndul	B6.129-Rgs3^tm1Ndul	MGI:5572937

Genotype
MGI:5572937

hm1

• Allelic Composition: Rgs3^tm1Ndul/Rgs3^tm1Ndul
• Genetic Background: B6.129-Rgs3^tm1Ndul

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:210195 )

N • mice exhibit no immune defects with normal T cell effector function and proliferation

increased B cell number ( J:210195 )

• in the bronchoalveolar lavage fluid and lungs following exposure to house dust mite to induce allergic airway inflammation

increased CD4-positive, alpha-beta T cell number ( J:210195 )

• in the bronchoalveolar lavage fluid and lungs following exposure to house dust mite to induce allergic airway inflammation

increased CD8-positive, alpha-beta T cell number ( J:210195 )

• in the bronchoalveolar lavage fluid and lungs following exposure to house dust mite to induce allergic airway inflammation

abnormal lymph node morphology ( J:210195 )

• decreased total cellularity of mediastinal lymph nodes following exposure to house dust mite to induce allergic airway inflammation

increased susceptibility to type I hypersensitivity reaction ( J:210195 )

• following exposure to house dust mite to induce allergic airway inflammation, mice exhibit increased overall cellular infiltration in the lungs and directly surrounding vessels, increased B, CD4+ T and CD8+ T cells in the bronchoalveolar lavage fluid and lungs, reduced T cells in the lung draining lymph node and decreased total cellularity of mediastinal lymph nodes compared with wild-type mice

lung inflammation ( J:210195 )

• increased overall cellular infiltration in the lungs and directly surrounding vessels following exposure to house dust mite to induce allergic airway inflammation

respiratory system

lung inflammation ( J:210195 )

• increased overall cellular infiltration in the lungs and directly surrounding vessels following exposure to house dust mite to induce allergic airway inflammation

hematopoietic system

increased B cell number ( J:210195 )

• in the bronchoalveolar lavage fluid and lungs following exposure to house dust mite to induce allergic airway inflammation

increased CD4-positive, alpha-beta T cell number ( J:210195 )

• in the bronchoalveolar lavage fluid and lungs following exposure to house dust mite to induce allergic airway inflammation

increased CD8-positive, alpha-beta T cell number ( J:210195 )

• in the bronchoalveolar lavage fluid and lungs following exposure to house dust mite to induce allergic airway inflammation