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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tnfrsf1atm3.1Gkl
targeted mutation 3.1, George Kollias
MGI:5572949
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Tnfrsf1atm3.1Gkl/Tnfrsf1a+
Tg(Vil1-cre)997Gum/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL MGI:5573122
cn2
Tnfrsf1atm3.1Gkl/Tnfrsf1atm3.1Gkl
Tg(Vil1-cre)997Gum/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL MGI:5573123


Genotype
MGI:5573122
cn1
Allelic
Composition
Tnfrsf1atm3.1Gkl/Tnfrsf1a+
Tg(Vil1-cre)997Gum/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Vil1-cre)997Gum mutation (2 available)
Tnfrsf1atm3.1Gkl mutation (1 available); any Tnfrsf1a mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

homeostasis/metabolism
• mice subjected to TNF challenge exhibit decreased lethality and a reduced loss of intestinal barrier function compared with wild-type mice




Genotype
MGI:5573123
cn2
Allelic
Composition
Tnfrsf1atm3.1Gkl/Tnfrsf1atm3.1Gkl
Tg(Vil1-cre)997Gum/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Vil1-cre)997Gum mutation (2 available)
Tnfrsf1atm3.1Gkl mutation (1 available); any Tnfrsf1a mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• in mice challenged with TNF
• in B17BL6 tumor-bearing mice treated with TNF and IFN-gamma

homeostasis/metabolism
• mice subjected to TNF challenge exhibit decreased lethality and a reduced loss of intestinal barrier function compared with wild-type mice





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory