About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnfrsf1atm4.1(TNFRSF1A)Gkl
targeted mutation 4.1, George Kollias
MGI:5572951
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Tnfrsf1atm4.1(TNFRSF1A)Gkl/Tnfrsf1a+ involves: 129P2/OlaHsd MGI:5573125


Genotype
MGI:5573125
ht1
Allelic
Composition		 Tnfrsf1atm4.1(TNFRSF1A)Gkl/Tnfrsf1a+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm4.1(TNFRSF1A)Gkl mutation (0 available); any Tnfrsf1a mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to induced morbidity/mortality ( J:210950 )
• in TNF-treated mice following administration of an antibody that neutralizes the knock-in protein

neoplasm
tumor regression ( J:210950 )
• of subcutaneous B16BL6 tumor cells in mice treated with TNF and IFN-gamma without systemic toxicity following administration of an antibody that neutralizes the knock-in protein




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory