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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnfrsf1atm4.1(TNFRSF1A)Gkl
targeted mutation 4.1, George Kollias
MGI:5572951
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Tnfrsf1atm4.1(TNFRSF1A)Gkl/Tnfrsf1a+ involves: 129P2/OlaHsd MGI:5573125


Genotype
MGI:5573125
ht1
Allelic
Composition		 Tnfrsf1atm4.1(TNFRSF1A)Gkl/Tnfrsf1a+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm4.1(TNFRSF1A)Gkl mutation (0 available); any Tnfrsf1a mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to induced morbidity/mortality ( J:210950 )
• in TNF-treated mice following administration of an antibody that neutralizes the knock-in protein

neoplasm
tumor regression ( J:210950 )
• of subcutaneous B16BL6 tumor cells in mice treated with TNF and IFN-gamma without systemic toxicity following administration of an antibody that neutralizes the knock-in protein




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory