All Phenotypes Cdkl5<tm1.2Cogr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cdkl5^tm1.2Cogr
targeted mutation 1.2, Cornelius Gross
MGI:5573238

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdkl5^tm1.2Cogr/Cdkl5^tm1.2Cogr	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J	MGI:5574073
ht2	Cdkl5^tm1.2Cogr/Cdkl5⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J	MGI:5574072
cx3	Cdkl5^tm1.2Cogr/Y Tg(Thy1-YFP)#Jrs/0	involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA	MGI:5574075
cx4	Cdkl5^tm1.2Cogr/Cdkl5^tm1.2Cogr Tg(Thy1-YFP)#Jrs/0	involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA	MGI:5574076
cx5	Cdkl5^tm1.2Cogr/Cdkl5⁺ Tg(Thy1-YFP)#Jrs/0	involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA	MGI:5574077
ot6	Cdkl5^tm1.2Cogr/Y	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J	MGI:5574074

Allelic Composition	Cdkl5^tm1.2Cogr/Cdkl5^tm1.2Cogr
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkl5^tm1.2Cogr mutation (2 available); any Cdkl5 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Hind-limb clasping in Cdkl5^tm1.2Cogr/Cdkl5^tm1.2Cogr mice

behavior/neurological

limb grasping ( J:209635 )

decreased locomotor activity ( J:209635 )

• in the home cage

• however, activity in a novel open arena is normal

seizures ( J:209635 )

• longer mean duration of high-amplitude bursts and lower frequency as detected by electroencephalographic (EEG) recordings

• however, mice exhibit normal spontaneous and induced seizure occurrences

abnormal seizure response to inducing agent ( J:209635 )

• mice treated with kainic acid fail to exhibit an increase in dose-dependent low frequency EEG power unlike wild-type mice

• however, mice exhibit normal spontaneous and induced seizure occurrences

nervous system

seizures ( J:209635 )

• longer mean duration of high-amplitude bursts and lower frequency as detected by electroencephalographic (EEG) recordings

• however, mice exhibit normal spontaneous and induced seizure occurrences

abnormal seizure response to inducing agent ( J:209635 )

• mice treated with kainic acid fail to exhibit an increase in dose-dependent low frequency EEG power unlike wild-type mice

• however, mice exhibit normal spontaneous and induced seizure occurrences

vision/eye

abnormal visual evoked potential ( J:209635 )

• decreased amplitude, but not latency, of the first positive wave

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
developmental and epileptic encephalopathy 2		DOID:0080467	OMIM:300672	J:209635

Allelic Composition	Cdkl5^tm1.2Cogr/Cdkl5⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkl5^tm1.2Cogr mutation (2 available); any Cdkl5 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

limb grasping ( J:209635 )

decreased locomotor activity ( J:209635 )

• intermediate in the home cage

• however, activity in a novel open arena is normal

vision/eye

abnormal visual evoked potential ( J:209635 )

• decreased amplitude, but not latency, of the first positive wave

Allelic Composition	Cdkl5^tm1.2Cogr/Y Tg(Thy1-YFP)#Jrs/0
Genetic Background	involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkl5^tm1.2Cogr mutation (2 available); any Cdkl5 mutation (20 available)
Tg(Thy1-YFP)#Jrs mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal hippocampus layer morphology ( J:209635 )

• reduced thickness

thin hippocampus molecular cell layer ( J:209635 )

thin hippocampus stratum oriens ( J:209635 )

thin cerebral cortex ( J:209635 )

abnormal dendrite morphology ( J:209635 )

• reduced total length of apical dendritic arbors of cortical and hippocampal pyramidal neurons

• reduced branching of pyramidal neuron dendrites

Allelic Composition	Cdkl5^tm1.2Cogr/Cdkl5^tm1.2Cogr Tg(Thy1-YFP)#Jrs/0
Genetic Background	involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkl5^tm1.2Cogr mutation (2 available); any Cdkl5 mutation (20 available)
Tg(Thy1-YFP)#Jrs mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal hippocampus layer morphology ( J:209635 )

• reduced thickness

thin hippocampus molecular cell layer ( J:209635 )

thin hippocampus stratum oriens ( J:209635 )

thin cerebral cortex ( J:209635 )

abnormal dendrite morphology ( J:209635 )

• reduced total length of apical dendritic arbors of cortical and hippocampal pyramidal neurons

• reduced branching of pyramidal neuron dendrites

Allelic Composition	Cdkl5^tm1.2Cogr/Cdkl5⁺ Tg(Thy1-YFP)#Jrs/0
Genetic Background	involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkl5^tm1.2Cogr mutation (2 available); any Cdkl5 mutation (20 available)
Tg(Thy1-YFP)#Jrs mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

thin cerebral cortex ( J:209635 )

• intermediate

abnormal dendrite morphology ( J:209635 )

• intermediate reduction in total length of apical dendritic arbors of cortical and hippocampal pyramidal neurons with bimodal distribution

Allelic Composition	Cdkl5^tm1.2Cogr/Y
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkl5^tm1.2Cogr mutation (2 available); any Cdkl5 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

limb grasping ( J:209635 )

decreased locomotor activity ( J:209635 )

• in the home cage

• however, activity in a novel open arena is normal

seizures ( J:209635 )

• longer mean duration of high-amplitude bursts and lower frequency as detected by electroencephalographic (EEG) recordings

• however, mice exhibit normal spontaneous and induced seizure occurrences

abnormal seizure response to inducing agent ( J:209635 )

• mice treated with kainic acid fail to exhibit an increase in dose-dependent low frequency EEG power unlike wild-type mice

• however, mice exhibit normal spontaneous and induced seizure occurrences

nervous system

seizures ( J:209635 )

• longer mean duration of high-amplitude bursts and lower frequency as detected by electroencephalographic (EEG) recordings

• however, mice exhibit normal spontaneous and induced seizure occurrences

abnormal seizure response to inducing agent ( J:209635 )

• mice treated with kainic acid fail to exhibit an increase in dose-dependent low frequency EEG power unlike wild-type mice

• however, mice exhibit normal spontaneous and induced seizure occurrences

vision/eye

abnormal visual evoked potential ( J:209635 )

• decreased amplitude, but not latency, of the first positive wave

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
developmental and epileptic encephalopathy 2		DOID:0080467	OMIM:300672	J:209635

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