Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1(CAG-Bcl3,-EGFP)Hoev}
• Allele Name: targeted mutation 1, Nadine Hovelmeyer
• Allele ID: MGI:5574111
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor^+ Cd19^tm1(cre)Cgn/Cd19^+	involves: 129P2/OlaHsd	MGI:5574113

Genotype
MGI:5574113

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Bcl3,-EGFP)Hoev}/Gt(ROSA)26Sor⁺; Cd19^tm1(cre)Cgn/Cd19⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B cell apoptosis ( J:208980 )

• of follicular II B cells in the spleen

decreased B cell proliferation ( J:208980 )

• of follicular I and follicular II B cells in the spleen

• of B cells stimulated with LPS, CpG or anti-IgM F(ab)'2 in vivo or in vitro

enlarged spleen ( J:208980 )

abnormal B cell differentiation ( J:208980 )

• impaired marginal zone B cell differentiation

abnormal class switch recombination ( J:208980 )

• reduced number of class switched IgG1 B cells in the Peyer's patch

• almost complete block of class switch to IgA, IgG1, IgG2b and IgG3

decreased immature B cell number ( J:208980 )

• in the spleen

decreased transitional stage T1 B cell number ( J:208980 )

• in the spleen

abnormal transitional stage T3 B cell morphology ( J:208980 )

• increased percent

decreased B-1 B cell number ( J:208980 )

decreased B-1a cell number ( J:208980 )

decreased marginal zone B cell number ( J:208980 )

absent marginal zone B cells ( J:208980 )

• absence of the marginal zone B cells peripheral to follicles in the spleen

increased lymphocyte cell number ( J:208980 )

• in the spleen

abnormal B-2 B cell morphology ( J:208980 )

• increased percentage in the peritoneal cavity

abnormal follicular B cell morphology ( J:208980 )

• decreased follicular II B cell compartment and increase in follicular I B cell numbers in the spleen

decreased IgG1 level ( J:208980 )

• following immunization with NP-CG antigen

• however, levels in naive mice are normal

decreased IgG2b level ( J:208980 )

• following immunization with NP-CG antigen

decreased IgG3 level ( J:208980 )

• in naive mice and following immunization with NP-Ficoll

decreased IgM level ( J:208980 )

• in naive mice and following immunization with NP-Ficoll

• however, levels are normal following immunization with NP-CG antigen

abnormal Peyer's patch germinal center morphology ( J:208980 )

• reduced development with reduced number of class switched IgG1 B cells in the Peyer's patch

cellular

decreased B cell apoptosis ( J:208980 )

• of follicular II B cells in the spleen

decreased B cell proliferation ( J:208980 )

• of follicular I and follicular II B cells in the spleen

• of B cells stimulated with LPS, CpG or anti-IgM F(ab)'2 in vivo or in vitro

hematopoietic system

decreased B cell apoptosis ( J:208980 )

• of follicular II B cells in the spleen

decreased B cell proliferation ( J:208980 )

• of follicular I and follicular II B cells in the spleen

• of B cells stimulated with LPS, CpG or anti-IgM F(ab)'2 in vivo or in vitro

enlarged spleen ( J:208980 )

abnormal B cell differentiation ( J:208980 )

• impaired marginal zone B cell differentiation

abnormal class switch recombination ( J:208980 )

• reduced number of class switched IgG1 B cells in the Peyer's patch

• almost complete block of class switch to IgA, IgG1, IgG2b and IgG3

decreased immature B cell number ( J:208980 )

• in the spleen

decreased transitional stage T1 B cell number ( J:208980 )

• in the spleen

abnormal transitional stage T3 B cell morphology ( J:208980 )

• increased percent

decreased B-1 B cell number ( J:208980 )

decreased B-1a cell number ( J:208980 )

decreased marginal zone B cell number ( J:208980 )

absent marginal zone B cells ( J:208980 )

• absence of the marginal zone B cells peripheral to follicles in the spleen

increased lymphocyte cell number ( J:208980 )

• in the spleen

abnormal B-2 B cell morphology ( J:208980 )

• increased percentage in the peritoneal cavity

abnormal follicular B cell morphology ( J:208980 )

• decreased follicular II B cell compartment and increase in follicular I B cell numbers in the spleen

decreased IgG1 level ( J:208980 )

• following immunization with NP-CG antigen

• however, levels in naive mice are normal

decreased IgG2b level ( J:208980 )

• following immunization with NP-CG antigen

decreased IgG3 level ( J:208980 )

• in naive mice and following immunization with NP-Ficoll

decreased IgM level ( J:208980 )

• in naive mice and following immunization with NP-Ficoll

• however, levels are normal following immunization with NP-CG antigen

growth/size/body

enlarged spleen ( J:208980 )